CAS 7357-67-7

4-(3-chloropropyl)morpholine

Codes: GEFT-003

Application context (from source-drug indications)

Non-small cell lung cancerGefitinibLung cancerGefitinibHead and neck cancerGefitinibBreast cancerGefitinib唇肿瘤Gefitinib喉肿瘤Gefitinib

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Gefitinib	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

GefitinibOptimised routesteps: 8total yield: 0.12 g

3-hydroxy-4-methoxybenzaldehyde→3-hydroxy-4-methoxybenzonitrile→4-(3-chloropropyl)morpholine→4-methoxy-3-(3-morpholinopropoxy)benzonitrile→4-methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile→2-amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile→2-amino-4-methoxy-5-(3-morpholinopropoxy)benzamide→7-methoxy-6-(3-morpholinopropoxy)quinazolin-4(1H)-one→4-(3-((4-chloro-7-methoxyquinazolin-6-yl)oxy)propyl)morpholine→3-chloro-4-fluoroaniline

GefitinibOriginator routesteps: 6total yield: 29.5 g

4-(3-chloropropyl)morpholine→3-chloro-4-fluoroaniline→6,7-dimethoxyquinazolin-4(3H)-one→L-methionine→6-hydroxy-7-methoxyquinazolin-4(3H)-one→7-methoxy-4-oxo-3,4-dihydroquinazolin-6-yl acetate→4-chloro-7-methoxyquinazolin-6-yl acetate hydrochloride→4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate→4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-ol

GefitinibOptimised routesteps: 6total yield: 0.48 g

3-hydroxy-4-methoxybenzaldehyde→3-hydroxy-4-methoxybenzonitrile→4-(3-chloropropyl)morpholine→4-methoxy-3-(3-morpholinopropoxy)benzonitrile→4-methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile→2-amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile→3-chloro-4-fluoroaniline→(E)-N,N'-bis(3-chloro-4-fluorophenyl)formimidamide

GefitinibOptimised routesteps: 6total yield: 66.7 g

4-(3-chloropropyl)morpholine→3-chloro-4-fluoroaniline→6-hydroxy-7-methoxyquinazolin-4(3H)-one→4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-ol→3,4-dimethoxybenzoic acid→4,5-dimethoxy-2-nitrobenzoic acid→2-amino-5-hydroxy-4-methoxybenzoic acid

Intermediates available on this site

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Supplier	Product	Price band	MOQ	Lead time	Qualifications	Action
Unibest Taizhou GMP-like Site	N-(3-Chloropropyl)morpholine Pharmaceutical Intermediates	On request	On request	On request	—

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