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CAS 73874-95-0
1,1-Dimethylethyl piperidin-4-ylcarbamate
Codes: (IV)1055986-1-a,(IV)1055986-1-c, (VIII)1157260-1-a, (VI)1157260-2-a
Application context (from source-drug indications)
AcromegalyPaltusotineIntestinal neoplasmPaltusotine恶性类癌综合征PaltusotineDiarrhoeaPaltusotineLiver cancerPaltusotine回肠肿瘤PaltusotineNon-small cell lung cancerZongertinibLung cancerZongertinib食道腺癌Zongertinib食管胃结合部肿瘤ZongertinibGastric cancerZongertinibMetastatic breast cancerZongertinib
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Paltusotine | Tier C — Watch / trade | - |
| Zongertinib | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
6-Bromoquinolin-4-ol→6-Bromo-3-chloroquinolin-4-ol→4,6-Dibromo-3-chloroquinoline→1,1-Dimethylethyl piperidin-4-ylcarbamate→N-Boc-1-(6-bromo-3-chloroquinolin-4-yl)piperidin-4-amine→6-Bromo-4-chloroquinoline→N-Boc-1-(6-bromoquinolin-4-yl)piperidin-4-amine→2-Hydroxy-3-cyano-potassium phenyltrifluoro borate→(3-Cyano-2-hydroxyphenyl)boronic acid→N-Boc-3-[4-(4-aminopiperidin-1-yl)-3-chloroquinolin-6-yl]-2-hydroxybenzonitrile→(3,5-Difluorophenyl)Boranediol→N-Boc-1-(6-(3-cyano-2-hydroxyphenyl)-3-(3,5-difluorophenyl)quinolin-4-yl)piperidin-4-amine→3-[4-(4-Aminopiperidin-1-yl)-3-(3,5-difluorophenyl)quinolin-6-yl]-2-hydroxybenzonitrile dihydrogen chloride→3-[4-(4-Aminopiperidin-1-yl)-3-(3,5-difluorophenyl)quinolin-6-yl]-2-hydroxybenzonitrile→2-Bromo-6-cyanophenol→3-Bromo-2-(methoxymethoxy)benzonitrile
1,1-Dimethylethyl piperidin-4-ylcarbamate→N-Boc-1-(6-bromo-3-chloroquinolin-4-yl)piperidin-4-amine→(3,5-Difluorophenyl)Boranediol→3-[4-(4-Aminopiperidin-1-yl)-3-(3,5-difluorophenyl)quinolin-6-yl]-2-hydroxybenzonitrile→6-Bromo-3,4-dichloroquinoline→2-[(2-Methoxyethoxy)methoxy]-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile→N-Boc-1-(3-chloro-6-[3-cyano-2-(2-methoxy-ethoxymethoxy)-phenyl]-quinolin-4-yl)-piperidin-4-amine→tert-Butyl [1-[3-chloro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinolin-4-yl]piperidin-4-yl]carbamate→3-Bromo-2-[(2-methoxyethoxy)methoxy]benzonitrile→tert-Butyl [1-[6-[3-cyano-2-[(2-methoxyethoxy)methoxy]phenyl]-3-(3,5-difluorophenyl)quinolin-4-yl]piperidin-4-yl]carbamate
1-Fluoro-2-methyl-4-nitrobenzene→1-Methyl-1H-1,3-benzimidazol-5-ol→1-Methyl-5-(2-methyl-4-nitrophenoxy)-1H-1,3-benzimidazole→3-Methyl-4-((1-methyl-1H-benzimidazol-5-yl)oxy)benzenamine→4-Chloro-6-(methylthio)pyrimido[5,4-d]pyrimidine→8-Chloro-2-(methylsulfanyl)pyrimido[5,4-d]pyrimidine hydrogen chloride→N-[3-Methyl-4-[(1-methyl-1H-1,3-benzimidazol-5-yl)oxy]phenyl]-6-(methylsulfanyl)pyrimido[5,4-d]pyrimidin-4-amine→6-(Methanesulfinyl)-N-[3-methyl-4-[(1-methyl-1H-1,3-benzimidazol-5-yl)oxy]phenyl]pyrimido[5,4-d]pyrimidin-4-amine→1,1-Dimethylethyl piperidin-4-ylcarbamate→tert-Butyl [1-(8-[3-methyl-4-[(1-methyl-1H-1,3-benzimidazol-5-yl)oxy]anilino]pyrimido[5,4-d]pyrimidin-2-yl)piperidin-4-yl]carbamate→6-(4-Aminopiperidin-1-yl)-N-[3-methyl-4-[(1-methyl-1H-1,3-benzimidazol-5-yl)oxy]phenyl]pyrimido[5,4-d]pyrimidin-4-amine→2-Propenoyl chloride
6-(Methylsulfanyl)-[1,3]diazino[5,4-d]pyrimidin-4-ol→4-Chloro-6-(methylthio)pyrimido[5,4-d]pyrimidine→3-Methyl-4-((1-methyl-1H-benzimidazol-5-yl)oxy)benzenamine→N-[3-Methyl-4-[(1-methyl-1H-1,3-benzimidazol-5-yl)oxy]phenyl]-6-(methylsulfanyl)pyrimido[5,4-d]pyrimidin-4-amine→N-[3-Methyl-4-[(1-methyl-1H-1,3-benzimidazol-5-yl)oxy]phenyl]-6-(methylsulfanyl)pyrimido[5,4-d]pyrimidin-4-amine hydrogen chloride→6-(Methanesulfonyl)-N-[3-methyl-4-[(1-methyl-1H-1,3-benzimidazol-5-yl)oxy]phenyl]pyrimido[5,4-d]pyrimidin-4-amine→1,1-Dimethylethyl piperidin-4-ylcarbamate→tert-Butyl [1-(8-[3-methyl-4-[(1-methyl-1H-1,3-benzimidazol-5-yl)oxy]anilino]pyrimido[5,4-d]pyrimidin-2-yl)piperidin-4-yl]carbamate→6-(4-Aminopiperidin-1-yl)-N-[3-methyl-4-[(1-methyl-1H-1,3-benzimidazol-5-yl)oxy]phenyl]pyrimido[5,4-d]pyrimidin-4-amine hydrogen chloride (1/3)→(Chloromethyl)acetyl chloride→3-Chloro-N-[1-(8-[3-methyl-4-[(1-methyl-1H-1,3-benzimidazol-5-yl)oxy]anilino]pyrimido[5,4-d]pyrimidin-2-yl)piperidin-4-yl]propanamide
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