← Back to patent-cliff list
CAS 74-89-5
AminomethaneMethylamine
Codes: (X)819703-1-a, (X)819703-2-a, (VI)819703-3-a, Ephedrine Sulfate-005, Lercanidipine Hydrochloride-021, Phenylephrine Hydrochloride-038, Pilocarpine Nitrate-013, (II)275500-4-a, (VI)275500-5-a, (VI)275500-6-a, Granisetron-020
Application context (from source-drug indications)
Gastrointestinal stromal tumourRipretinibHypotensionEphedrine SulfateEssential hypertensionValsartan/Lercanidipine HydrochlorideCommon coldIbuprofen/Phenylephrine HydrochlorideFeverIbuprofen/Phenylephrine HydrochlorideHeadacheIbuprofen/Phenylephrine HydrochlorideGlaucomaProxodolol hydrochloride/Pilocarpine HydrochlorideHypertensionLercanidipine HydrochlorideMydriasisPhenylephrine HydrochlorideHypotensionPhenylephrine HydrochlorideCycloplegiaPhenylephrine HydrochlorideSupraventricular tachycardiaPhenylephrine HydrochlorideShockPhenylephrine HydrochlorideIschaemic strokePhenylephrine Hydrochloride闭角型青光眼Pilocarpine HydrochlorideOcular hypertensionPilocarpine HydrochlorideOpen-angle glaucomaPilocarpine Hydrochloride瞳孔缩小Pilocarpine HydrochlorideSjögren's syndromePilocarpine Hydrochloride虹膜炎Pilocarpine HydrochlorideAllergic reactionEpinephrine intranasal spray (ARS Pharmaceuticals)Chronic urticariaEpinephrine intranasal spray (ARS Pharmaceuticals)UrticariaEpinephrine intranasal spray (ARS Pharmaceuticals)AsthmaEpinephrine intranasal spray (ARS Pharmaceuticals)Respiratory tract infectionEpinephrine intranasal spray (ARS Pharmaceuticals)Chemotherapy-induced nausea and vomitingGranisetronNauseaGranisetron呕吐Granisetron手术后恶心呕吐GranisetronPostoperative painGranisetronGastroparesisGranisetron
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Ripretinib | Tier C — Watch / trade | 2032 |
| Ephedrine Sulfate | Tier C — Watch / trade | - |
| Valsartan/Lercanidipine Hydrochloride | Tier C — Watch / trade | - |
| Ibuprofen/Phenylephrine Hydrochloride | Tier C — Watch / trade | - |
| Proxodolol hydrochloride/Pilocarpine Hydrochloride | Tier C — Watch / trade | - |
| Lercanidipine Hydrochloride | Tier C — Watch / trade | - |
| Phenylephrine Hydrochloride | Tier C — Watch / trade | - |
| Pilocarpine Hydrochloride | Tier C — Watch / trade | - |
| Epinephrine intranasal spray (ARS Pharmaceuticals) | Tier C — Watch / trade | - |
| Granisetron | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
1,3-Acetonedicarboxylic acid diethyl ester→4,6-Dihydroxynicotinic acid ethyl ester→2,4-Dichloro-5-carbethoxypyridine→Aminoethane→6-Chloro-4-ethylamino-nicotinic acid ethyl ester→[6-Chloro-4-(ethylamino)pyridin-3-yl]methanol→6-Chloro-4-(ethylamino)nicotinaldehyde→Ethyl (5-amino-2-bromo-4-fluorophenyl)acetate→3-(5-Amino-2-bromo-4-fluorophenyl)-7-chloro-1-ethyl-1,6-naphthyridin-2(1H)-one→Aminomethane→3-(5-Amino-2-bromo-4-fluorophenyl)-1-ethyl-7-(methylamino)-1,6-naphthyridin-2(1H)-one→3-(5-Amino-2-bromo-4-fluorophenyl)-1-ethyl-7-(methylamino)-1,6-naphthyridin-2(1H)-one hydrochloride→4-Isocyanatobenzene→Carbanilic acid phenyl ester→2-(2-Bromo-4-fluorophenyl)acetic acid→(2-Bromo-4-fluoro-5-nitrophenyl)acetic acid→Ethyl (2-bromo-4-fluoro-5-nitrophenyl)acetate
Methyl (2-bromo-4-fluoro-5-nitrophenyl)acetate→6-Chloro-4-nitropyridine-3-carbaldehyde→Methyl (2Z)-2-(2-bromo-4-fluoro-5-nitrophenyl)-3-(6-chloro-4-nitropyridin-3-yl)prop-2-enoate→3-(5-Amino-2-bromo-4-fluorophenyl)-7-chloro-1,6-naphthyridin-2(1H)-one→Aminobenzene→1,1,1-Trichloromethanol 1,1'-carbonate→N-[4-Bromo-5-(7-chloro-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl]-N'-phenylurea→1-Iodoethane→N-[4-Bromo-5-(7-chloro-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl]-N'-phenylurea→Aminomethane
(2-Bromo-4-fluoro-5-nitrophenyl)acetic acid→Carbanilic acid phenyl ester→Ethyl [2-bromo-4-fluoro-5-[(phenylcarbamoyl)amino]phenyl]acetate→6-Chloro-4-(ethylamino)nicotinaldehyde→N-[4-Bromo-5-(7-chloro-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl]-N'-phenylurea→Aminomethane
Benzene→2-Chloropropanoyl chloride→2-Chloro-1-phenylpropan-1-one→alpha-Bromopropiophenone→Methylamine→2-(Methylamino)-1-phenylpropan-1-one→(2R,3R)-2,3-Bis(benzoyloxy)butanedioic acid (2S)-2-(methylamino)-1-phenylpropan-1-one (1/2)→(2R,3R)-2,3-Bis(benzoyloxy)butanedioic acid (1R,2S)-2-(methylamino)-1-phenylpropan-1-ol (1/2)→(-)-2(S)-(Methylamino)-1(R)-phenylpropan-1-ol hydrochloride→(-)-2(S)-(Methylamino)-1(R)-phenylpropan-1-ol
Ethyl phenyl ketone→1-Phenylpropane-1,2-dione 2-oxime→(1R,2E)-2-(Hydroxyimino)-1-phenylpropan-1-ol→(1R)-1-Hydroxy-1-phenylpropan-2-one→Methylamine→(-)-2(S)-(Methylamino)-1(R)-phenylpropan-1-ol→Benzaldehyde→2-Oxopropionic acid
Propiophenone→Dimethyl (2S,3S)-2,3-dihydroxysuccinate→Dimethyl (4S,5S)-2-ethyl-2-phenyl-1,3-dioxolane-4,5-dicarboxylate→Dimethyl (4S,5S)-2-[(1R)-1-bromoethyl]-2-phenyl-1,3-dioxolane-4,5-dicarboxylate→Methylamine→Dimethyl (4S,5S)-2-[(1S)-1-(methylamino)ethyl]-2-phenyl-1,3-dioxolane-4,5-dicarboxylate→(2S)-2-(Methylamino)-1-phenylpropan-1-one
(3,3-Diphenylpropyl)(methyl)amine→1,3-Diethyl propanedioate→1,1-Diphenylmethanol→Diethyl (diphenylmethyl)propanedioate→Ethyl 3,3-diphenylpropanoate→Methylamine→N-Methyl-3,3-diphenylpropanamide
3-Phenyl-2(E)-propenoic acid→(2E)-3-phenylprop-2-enoyl chloride→Methylamine→N-Methyl-3-phenylacrylamide→Benzene→N-Methyl-3,3-diphenylpropanamide→(3,3-Diphenylpropyl)(methyl)amine→1-Chloro-2-methyl-2-propanol→1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-ol→Methyl 5-[[(diethoxyphosphoryl)oxy]carbonyl]-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate→(+/-)-5-(Methoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3-pyridinecarboxylic acid
Proxodolol hydrochloride/Pilocarpine HydrochlorideRoute 1steps: 10total yield: 150mg(Pilocarpine Nitrate (API))
2-(2,2-Dimethoxyethyl)propane-1,3-diol→2-[(Acetyloxy)methyl]-4,4-dimethoxybutyl acetate→(2R)-2-(Hydroxymethyl)-4,4-dimethoxybutyl acetate→(2S)-2-Formyl-4,4-dimethoxybutyl acetate→Vinylmagnesium bromide→(2S)-2-(2,2-Dimethoxyethyl)pent-4-ene-1,3-diol→(5S)-5-(2,2-Dimethoxyethyl)-4-ethenyl-1,3-dioxan-2-one→(3R,4R)-4-(2,2-Dimethoxyethyl)-3-ethenyldihydrofuran-2(3H)-one→[(3R,4R)-4-Ethenyl-5-oxotetrahydrofuran-3-yl]acetaldehyde→Methylamine→(4R)-3-Ethylidene-4-[(2E)-2-(methylimino)ethyl]dihydrofuran-2(3H)-one→(3E,4R)-3-Ethylidene-4-[(1-methyl-1H-imidazol-5-yl)methyl]dihydrofuran-2(3H)-one
(3,3-Diphenylpropyl)(methyl)amine→1,3-Diethyl propanedioate→1,1-Diphenylmethanol→Diethyl (diphenylmethyl)propanedioate→Ethyl 3,3-diphenylpropanoate→Methylamine→N-Methyl-3,3-diphenylpropanamide
3-Phenyl-2(E)-propenoic acid→(2E)-3-phenylprop-2-enoyl chloride→Methylamine→N-Methyl-3-phenylacrylamide→Benzene→N-Methyl-3,3-diphenylpropanamide→(3,3-Diphenylpropyl)(methyl)amine→1-Chloro-2-methyl-2-propanol→1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-ol→Methyl 5-[[(diethoxyphosphoryl)oxy]carbonyl]-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate→(+/-)-5-(Methoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3-pyridinecarboxylic acid
2-(2,2-Dimethoxyethyl)propane-1,3-diol→2-[(Acetyloxy)methyl]-4,4-dimethoxybutyl acetate→(2R)-2-(Hydroxymethyl)-4,4-dimethoxybutyl acetate→(2S)-2-Formyl-4,4-dimethoxybutyl acetate→Vinylmagnesium bromide→(2S)-2-(2,2-Dimethoxyethyl)pent-4-ene-1,3-diol→(5S)-5-(2,2-Dimethoxyethyl)-4-ethenyl-1,3-dioxan-2-one→(3R,4R)-4-(2,2-Dimethoxyethyl)-3-ethenyldihydrofuran-2(3H)-one→[(3R,4R)-4-Ethenyl-5-oxotetrahydrofuran-3-yl]acetaldehyde→Methylamine→(4R)-3-Ethylidene-4-[(2E)-2-(methylimino)ethyl]dihydrofuran-2(3H)-one→(3E,4R)-3-Ethylidene-4-[(1-methyl-1H-imidazol-5-yl)methyl]dihydrofuran-2(3H)-one
1,2-Dihydroxybenzene→2-O-Acetyl-3,4,6-tri-O-benzyl-alpha-D-glucopyranosyl bromide→2-Hydroxyphenyl 2-O-acetyl-3,4,6-tri-O-benzyl-beta-D-glucopyranoside→2-Chloranylethanoyl chloride→4-(Chloroacetyl)-2-hydroxyphenyl 2-O-acetyl-3,4,6-tri-O-benzyl-beta-D-glucopyranoside→Aminomethane→2-Hydroxy-4-[(methylamino)acetyl]phenyl 2-O-acetyl-3,4,6-tri-O-benzyl-beta-D-glucopyranoside→2-Hydroxy-4-[(1R)-1-hydroxy-2-(methylamino)ethyl]phenyl 2-O-acetyl-3,4,6-tri-O-benzyl-beta-D-glucopyranoside
Intermediates available on this site
No listed intermediates for this target yet — send an RFQ directly and it will enter our matching pool.
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.