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CAS 814-68-6
acryloyl chloride2-Propenoyl chlorideAcryloyl chloride2-Propenoyl chloride; Acrylic acid chloride; Acrylic chloride; Acryloyl chloride
Codes: OSIM-010, IBRT-008, (IX)461018-2-a, (IV)461018-6-a, (IX)461018-8-a, (XI)461018-10-a, (X)461018-11-a, (VII)461018-17-a, (X)461018-20-a, (IV)461018-21-a, (XI)461018-25-a, (XII)461018-28-a +8 more
Application context (from source-drug indications)
Non-small cell lung cancerOsimertinib MesylateWaldenström macroglobulinaemiaIbrutinibChronic lymphocytic leukaemiaIbrutinibMantle cell lymphomaIbrutinibGraft-versus-host diseaseIbrutinibNon-small cell lung cancerOlmutinibHIV infectionDarunavir Ethanolate/RitonavirHIV infectionDarunavir Ethanolate/CobicistatHIV infectionDarunavir EthanolateNon-small cell lung cancerFulzerasibColorectal cancerFulzerasibSolid tumourFulzerasibNon-small cell lung cancerLazertinib MesylateHepatic function declineLazertinib MesylateMarginal zone B-cell lymphomaOrelabrutinibMantle cell lymphomaOrelabrutinibChronic lymphocytic leukaemiaOrelabrutinibImmune thrombocytopenic purpuraOrelabrutinibSystemic lupus erythematosusOrelabrutinibMultiple sclerosisOrelabrutinib
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Osimertinib Mesylate | Tier A — Act now | 2031 |
| Ibrutinib | Tier A — Act now | 2027 |
| Olmutinib | Tier C — Watch / trade | - |
| Darunavir Ethanolate/Ritonavir | Tier C — Watch / trade | - |
| Darunavir Ethanolate/Cobicistat | Tier C — Watch / trade | - |
| Darunavir Ethanolate | Tier B — Position early | - |
| Fulzerasib | Tier C — Watch / trade | - |
| Lazertinib Mesylate | Tier C — Watch / trade | - |
| Orelabrutinib | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
1H-indole→2,4-dichloropyrimidine→3-(2-chloropyrimidin-4-yl)-1H-indole→3-(2-chloropyrimidin-4-yl)-1-methyl-1H-indole→4-fluoro-2-methoxy-5-nitroaniline→N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine→N1,N1,N2-trimethylethane-1,2-diamine→N1-(2-(dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)-2-nitrobenzene-1,4-diamine→N1-(2-(dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)benzene-1,2,4-triamine→acryloyl chloride→methanesulfonic acid
3-(2-chloropyrimidin-4-yl)-1-methyl-1H-indole→4-fluoro-2-methoxy-5-nitroaniline→N1,N1,N2-trimethylethane-1,2-diamine→acryloyl chloride→tert-butyl (4-fluoro-2-methoxy-5-nitrophenyl)carbamate→tert-butyl (4-((2-(dimethylamino)ethyl)(methyl)amino)-2-methoxy-5-nitrophenyl)carbamate→tert-butyl (5-amino-4-((2-(dimethylamino)ethyl)(methyl)amino)-2-methoxyphenyl)carbamate→N-(5-amino-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide
N1,N1,N2-trimethylethane-1,2-diamine→acryloyl chloride→N-(5-amino-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide→2-fluoro-4-iodoaniline→hexane-2,5-dione→1-(2-fluoro-4-iodophenyl)-2,5-dimethyl-1H-pyrrole→1-(2-fluoro-4-methoxyphenyl)-2,5-dimethyl-1H-pyrrole→2-fluoro-4-methoxyaniline→N-(2-fluoro-4-methoxyphenyl)acrylamide→N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide→N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-nitrophenyl)acrylamide→N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-guanidino-4-methoxyphenyl)acrylamide→(E)-3-(dimethylamino)-1-(1-methyl-1H-indol-3-yl)prop-2-en-1-one→1-(1-methyl-1H-indol-3-yl)ethanone
4-phenoxybenzoic acid→2-(hydroxy(4-phenoxyphenyl)methylene)malononitrile→2-(methoxy(4-phenoxyphenyl)methylene)malononitrile→5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile→3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine→(S)-tert-butyl 3-hydroxypiperidine-1-carboxylate→(R)-tert-butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate→acryloyl chloride→1H-pyrazolo[3,4-d]pyrimidin-4-amine→3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine→tert-butyl 4-(((6-amino-5-chloropyrimidin-4-yl)amino)methyl)piperidine-1-carboxylate
3-Bromo-1H-pyrazolo[3,4-d]pyrimidin-4-amine→(4-Phenoxyphenyl)boranediol→3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine→N-Boc-3(S)-Hydroxypiperidine→2-Propenoyl chloride→(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester→Perfluoroacetyl chloride→tert-Butyl (3R)-3-[3-(4-phenoxyphenyl)-4-[(trifluoroacetyl)amino]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate→2,2,2-Trifluoro-N-[3-(4-phenoxyphenyl)-1-[(3R)-piperidin-3-yl]-1H-pyrazolo[3,4-d]pyrimidin-4-yl]acetamide→N-[1-[(3R)-1-Acryloylpiperidin-3-yl]-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-2,2,2-trifluoroacetamide
(3S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine→(S)-1-tert-Butoxycarbonyl-3-(p-toluenesulfonyloxymethyl)piperidine→tert-Butyl (3S)-3-[[tert-butyl(dimethyl)silyl]oxy]piperidine-1-carboxylate→(3S)-Piperidin-3-yl 4-methylbenzenesulfonate→(3S)-3-[[tert-Butyl(dimethyl)silyl]oxy]piperidine→2-Propenoyl chloride→2-Propenoic acid→(3S)-1-Acryloylpiperidin-3-yl 4-methylbenzenesulfonate→1-[(3S)-3-[[tert-Butyl(dimethyl)silyl]oxy]piperidin-1-yl]prop-2-en-1-one→(3S)-1-Acryloylpiperidin-3-yl 4-nitrobenzenesulfonate→3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
3-Amino-1H-pyrazole-4-carbonitrile→Amide c1→1H-Pyrazolo[3,4-d]pyrimidin-4-amine→3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine→3-Bromo-1H-pyrazolo[3,4-d]pyrimidin-4-amine→2-Propenoyl chloride→(3S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine→(S)-1-(tert-Butoxycarbonyl)piperidin-3-yl methanesulfonate→tert-Butyl (3R)-3-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate→tert-Butyl (3R)-3-(4-amino-3-bromo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate→3-Iodo-1-[(3R)-piperidin-3-yl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine hydrogen chloride→3-Bromo-1-[(3R)-piperidin-3-yl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine→3-Iodo-1-[(3R)-piperidin-3-yl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine--hydrogen chloride (1→3-Iodo-1-[(3R)-piperidin-3-yl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine→2-Propenoic acid→1-[(3R)-3-(4-Amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl]prop-2-en-1-one→1-[(3R)-3-(4-Amino-3-bromo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl]prop-2-en-1-one→(4-Phenoxyphenyl)boranediol→(Chloromethyl)acetyl chloride→3-Bromopropanoyl bromide→1-[(3R)-3-(4-Amino-3-bromo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl]-3-chloropropan-1-one→1-[(3R)-3-(4-Amino-3-bromo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl]-3-bromopropan-1-one
4,6-Dihydroxypyrimidine→4,6-Dichloropyrimidine-5-carbaldehyde→1-Bromo-4-phenoxybenzene→(4,6-Dichloropyrimidin-5-yl)(4-phenoxyphenyl)methanol→(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester→(4,6-Dichloropyrimidin-5-yl)(4-phenoxyphenyl)methanone→(4-Amino-6-chloropyrimidin-5-yl)(4-phenoxyphenyl)methanone→3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine→N-Boc-3(S)-chloropiperidine→(R)-3-(4-phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine→3-(4-Phenoxyphenyl)-1-[(3R)-piperidin-3-yl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine hydrogen chloride→2-Propenoyl chloride→(Chloromethyl)acetyl chloride
1H-Pyrazolo[3,4-d]pyrimidin-4-amine→3-Bromo-1H-pyrazolo[3,4-d]pyrimidin-4-amine→(3S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine→(S)-1-(tert-Butoxycarbonyl)piperidin-3-yl methanesulfonate→tert-Butyl (3R)-3-(4-amino-3-bromo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate→tert-Butyl (3R)-3-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate→3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine→3-Bromo-1-[(3R)-piperidin-3-yl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine hydrogen chloride (1/2)→3-Iodo-1-[(3R)-piperidin-3-yl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine--hydrogen chloride (1/2)→3-(4-Phenoxyphenyl)-1-[(3R)-piperidin-3-yl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine hydrogen chloride→(4-Phenoxyphenyl)boranediol→(R)-3-(4-phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine→2-Propenoyl chloride
(3S)-Piperidin-3-ol--hydrogen chloride (1→2,2,2-Trifluoro-1-[(3S)-3-hydroxypiperidin-1-yl]ethan-1-one→3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine→1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]-2,2,2-trifluoroethan-1-one→2,2,2-Trifluoro-1-[(3R)-3-[3-(4-phenoxyphenyl)-4-[(triphenyl-lambda5-phosphanylidene)amino]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]ethan-1-one→(R)-3-(4-phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine→2-Propenoyl chloride
(3S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine→(3S)-Piperidin-3-ol--hydrogen chloride (1→(3S)-1-Benzylpiperidin-3-ol→(3S)-1-Benzylpiperidin-3-yl methanesulfonate→2-Propenoic acid→(3S)-Piperidin-3-yl methanesulfonate→3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine→1-[(3R)-1-Benzylpiperidin-3-yl]-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine→(R)-3-(4-phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine→2-Propenoyl chloride→1-[(3S)-3-Hydroxypiperidin-1-yl]prop-2-en-1-one→(3S)-1-(Prop-2-enoyl)piperidin-3-yl methanesulfonate
(3S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine→(3S)-1-(3,3-Dimethylbutanoyl)piperidin-3-yl 4-methylbenzene-1-sulfonate→(3S)-Piperidin-3-yl 4-methylbenzenesulfonate→2-Propenoyl chloride→(4-Phenoxyphenyl)boranediol→(3S)-1-Acryloylpiperidin-3-yl 4-methylbenzenesulfonate→3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine→1H-Pyrazolo[3,4-d]pyrimidin-4-amine→3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine
(3R)-3-Amino-1-piperidinecarboxylic acid 1,1-dimethylethyl ester→tert-Butyl (3R)-3-[(tert-butoxycarbonyl)(nitroso)amino]piperidine-1-carboxylate→tert-Butyl (3R)-3-[1-(tert-butoxycarbonyl)hydrazinyl]piperidine-1-carboxylate→(3R)-3-Hydrazinylpiperidine→Amide c1→1,1-Dicyano-2-methoxy-2-(4-phenoxyphenyl)ethene→4-Phenoxybenzoyl chloride→1,1-Dicyanomethane→5-Amino-3-(4-phenoxyphenyl)-1-[(3R)-piperidin-3-yl]-1H-pyrazole-4-carbonitrile→(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbaldehyde→2-Propenoyl chloride→3-Aminopiperidine→5-Oxo-D-proline (3R)-piperidin-3-amine→tert-Butyl (3R)-3-[(tert-butoxycarbonyl)amino]piperidine-1-carboxylate
tert-Butyl (3R)-3-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate→1-Benzyloxy-4-boronic acid→tert-Butyl (3R)-3-[4-amino-3-[4-(benzyloxy)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate→tert-Butyl (3R)-3-[3-[4-(benzyloxy)phenyl]-4-[bis(tert-butoxycarbonyl)amino]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate→([13C]-1,2,3,4,5,6)Phenylboronic acid→tert-Butyl (3R)-3-[4-[bis(tert-butoxycarbonyl)amino]-3-(4-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate→tert-Butyl (3R)-3-[4-[bis(tert-butoxycarbonyl)amino]-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate→(4-Hydroxyphenyl)boronic acid→1-Bromo(13C6)benzene→tert-Butyl (3R)-3-(4-[bis(tert-butoxycarbonyl)amino]-3-[4-[([13C]-1,2,3,4,5,6)phenyloxy]phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate→3-[4-[([13C]-1,2,3,4,5,6)Phenyloxy]phenyl]-1-[(3R)-piperidin-3-yl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine→2-Propenoyl chloride→1-[(3R)-3-(4-Amino-3-[4-[([13C]-1,2,3,4,5,6)phenyloxy]phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl]prop-2-en-1-one
4-Chloropyrimidine→tert-Butyl (3R)-3-[2-(tert-butoxycarbonyl)hydrazinyl]piperidine-1-carboxylate→tert-Butyl (3R)-3-[2-(tert-butoxycarbonyl)-1-(pyrimidin-4-yl)hydrazinyl]piperidine-1-carboxylate→4-Bromo-6-[1-[(3R)-piperidin-3-yl]hydrazinyl]pyrimidine→4-Phenoxybenzaldehyde→4-Bromo-3-(4-phenoxyphenyl)-1-[(3R)-piperidin-3-yl]-1H-pyrazolo[3,4-d]pyrimidine→(R)-3-(4-phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine→2-Propenoyl chloride
3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine→Di-tert-butyl [3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-2-imidodicarbonate→(3S)-1-Benzylpiperidin-3-ol→Di-tert-butyl [1-[(3R)-1-benzylpiperidin-3-yl]-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-2-imidodicarbonate→4,5,6,7-Tetrahydro-1H-indole→Di-tert-butyl [3-(4-phenoxyphenyl)-1-[(3R)-piperidin-3-yl]-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-2-imidodicarbonate→2-Propenoyl chloride→Di-tert-butyl [3-(4-phenoxyphenyl)-1-[(3R)-1-(prop-2-enoyl)piperidin-3-yl]-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-2-imidodicarbonate→Di-tert-butyl hydrazine-1,2-dicarboxylate→N'-(4,5,6,7-Tetrahydro-1H-indole-1-carbonyl)-4,5,6,7-tetrahydro-1H-indole-1-carbohydrazide
Methyl 3-aminothiophene-2-carboxylate→Urea→Thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione→2,4-dichlorothieno[3,2-d]pyrimidine→3-nitrophenol→2-chloro-4-(3-nitrophenoxy)thieno[3,2-d]pyrimidine→4-(4-methylpiperazin-1-yl)aniline→N-(4-(4-methylpiperazin-1-yl)phenyl)-4-(3-nitrophenoxy)thieno[3,2-d]pyrimidin-2-amine→4-(3-aminophenoxy)-N-(4-(4-methylpiperazin-1-yl)phenyl)thieno[3,2-d]pyrimidin-2-amine→Acryloyl chloride
(2R,3S)-3-iodo-2-(prop-2-yn-1-yloxy)tetrahydrofuran→(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol→bis(2,5-dioxopyrrolidin-1-yl) carbonate→2,5-dioxopyrrolidin-1-yl ((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl) carbonate→4-amino-N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-N-isobutylbenzenesulfonamide→2-(benzyloxy)acetaldehyde→vinylmagnesium bromide→1-(benzyloxy)but-3-en-2-ol→prop-1-en-2-yl acetate→(S)-1-(benzyloxy)but-3-en-2-ol→acryloyl chloride→(S)-1-(benzyloxy)but-3-en-2-yl acrylate→(S)-5-((benzyloxy)methyl)furan-2(5H)-one→1,3-dioxolane→(4S,5S)-5-((benzyloxy)methyl)-4-(1,3-dioxolan-2-yl)dihydrofuran-2(3H)-one→(4S,5S)-4-(1,3-dioxolan-2-yl)-5-(hydroxymethyl)dihydrofuran-2(3H)-one→(3S,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
(2R,3S)-3-iodo-2-(prop-2-yn-1-yloxy)tetrahydrofuran→(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol→bis(2,5-dioxopyrrolidin-1-yl) carbonate→2,5-dioxopyrrolidin-1-yl ((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl) carbonate→4-amino-N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-N-isobutylbenzenesulfonamide→2-(benzyloxy)acetaldehyde→vinylmagnesium bromide→1-(benzyloxy)but-3-en-2-ol→prop-1-en-2-yl acetate→(S)-1-(benzyloxy)but-3-en-2-ol→acryloyl chloride→(S)-1-(benzyloxy)but-3-en-2-yl acrylate→(S)-5-((benzyloxy)methyl)furan-2(5H)-one→1,3-dioxolane→(4S,5S)-5-((benzyloxy)methyl)-4-(1,3-dioxolan-2-yl)dihydrofuran-2(3H)-one→(4S,5S)-4-(1,3-dioxolan-2-yl)-5-(hydroxymethyl)dihydrofuran-2(3H)-one→(3S,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
(2R,3S)-3-iodo-2-(prop-2-yn-1-yloxy)tetrahydrofuran→(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol→bis(2,5-dioxopyrrolidin-1-yl) carbonate→2,5-dioxopyrrolidin-1-yl ((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl) carbonate→4-amino-N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-N-isobutylbenzenesulfonamide→2-(benzyloxy)acetaldehyde→vinylmagnesium bromide→1-(benzyloxy)but-3-en-2-ol→prop-1-en-2-yl acetate→(S)-1-(benzyloxy)but-3-en-2-ol→acryloyl chloride→(S)-1-(benzyloxy)but-3-en-2-yl acrylate→(S)-5-((benzyloxy)methyl)furan-2(5H)-one→1,3-dioxolane→(4S,5S)-5-((benzyloxy)methyl)-4-(1,3-dioxolan-2-yl)dihydrofuran-2(3H)-one→(4S,5S)-4-(1,3-dioxolan-2-yl)-5-(hydroxymethyl)dihydrofuran-2(3H)-one→(3S,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
tert-Butyl (4aR)-11-chloro-10-(2-fluoro-6-methoxyphenyl)-6-methyl-8-[4-methyl-2-(propan-2-yl)pyridin-3-yl]-5,7-dioxo-1,2,4,4a,5,6,7,8-octahydro-3H-pyrazino[1',2':4,5]pyrazino[2,3-c][1,8]naphthyridine-3-carboxylate→(4aR)-11-Chloro-10-(2-fluoro-6-methoxyphenyl)-6-methyl-8-[4-methyl-2-(propan-2-yl)pyridin-3-yl]-2,3,4,4a,6,8-hexahydro-1H-pyrazino[1',2':4,5]pyrazino[2,3-c][1,8]naphthyridine-5,7-dione→2-Propenoyl chloride→(4aR)-11-Chloro-10-(2-fluoro-6-methoxyphenyl)-6-methyl-8-[4-methyl-2-(propan-2-yl)pyridin-3-yl]-3-(prop-2-enoyl)-2,3,4,4a,6,8-hexahydro-1H-pyrazino[1',2':4,5]pyrazino[2,3-c][1,8]naphthyridine-5,7-dione
(aR)-6,7-Dichloro-4-hydroxy-1-(2-isopropyl-4-methyl-3-pyridyl)-1,8-naphthyridin-2-one→6,7-Dichloro-4-hydroxy-1-(2-isopropyl-4-methyl-3-pyridyl)-1,8-naphthyridin-2-one→(R)-Piperazine-1,3-dicarboxylic acid 1-tert-butyl 3-methyl diester→(aR)-6,7-Dichloro-4-hydroxy-1-(2-isopropyl-4-methyl-3-pyridyl)-3-nitro-1,8-naphthyridin-2-one→(aR)-6,7-Dichloro-1-[4-methyl-2-(propan-2-yl)pyridin-3-yl]-3-nitro-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl trifluoromethanesulfonate→(aR)-1-tert-Butyl 3-methyl (3R)-4-[6,7-dichloro-1-[4-methyl-2-(propan-2-yl)pyridin-3-yl]-3-nitro-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl]piperazine-1,3-dicarboxylate→(aR)-tert-Butyl (4aR)-10,11-dichloro-8-[4-methyl-2-(propan-2-yl)pyridin-3-yl]-5,7-dioxo-1,2,4,4a,5,6,7,8-octahydro-3H-pyrazino[1',2':4,5]pyrazino[2,3-c][1,8]naphthyridine-3-carboxylate→Dimethoxysulfone→(aR)-tert-Butyl (4aR)-10,11-dichloro-6-methyl-8-[4-methyl-2-(propan-2-yl)pyridin-3-yl]-5,7-dioxo-1,2,4,4a,5,6,7,8-octahydro-3H-pyrazino[1',2':4,5]pyrazino[2,3-c][1,8]naphthyridine-3-carboxylate→(2-Fluoro-6-hydroxyphenyl)boronic acid→(aR)-tert-Butyl (4aR)-11-chloro-10-(2-fluoro-6-hydroxyphenyl)-6-methyl-8-[4-methyl-2-(propan-2-yl)pyridin-3-yl]-5,7-dioxo-1,2,4,4a,5,6,7,8-octahydro-3H-pyrazino[1',2':4,5]pyrazino[2,3-c][1,8]naphthyridine-3-carboxylate→(aR)-(4aR)-11-Chloro-10-(2-fluoro-6-hydroxyphenyl)-6-methyl-8-[4-methyl-2-(propan-2-yl)pyridin-3-yl]-2,3,4,4a,6,8-hexahydro-1H-pyrazino[1',2':4,5]pyrazino[2,3-c][1,8]naphthyridine-5,7-dione→2-Propenoyl chloride
2-Amino-5-fluoro-4-nitroanisole→1-(2-Iodopyrimidin-4-yl)-3-phenyl-1H-pyrazole-4-carbaldehyde→1-[2-(4-Fluoro-2-methoxy-5-nitroanilino)pyrimidin-4-yl]-3-phenyl-1H-pyrazole-4-carbaldehyde→1-Oxa-4-azacyclohexane→1-[2-[2-Methoxy-4-(morpholin-4-yl)-5-nitroanilino]pyrimidin-4-yl]-3-phenyl-1H-pyrazole-4-carbaldehyde→Dimethylamine anhydrous→4-[4-[(Dimethylamino)methyl]-3-phenyl-1H-pyrazol-1-yl]-N-[2-methoxy-4-(morpholin-4-yl)-5-nitrophenyl]pyrimidin-2-amine→N1-[4-[4-[(Dimethylamino)methyl]-3-phenyl-1H-pyrazol-1-yl]pyrimidin-2-yl]-6-methoxy-4-(morpholin-4-yl)benzene-1,3-diamine→2-Propenoyl chloride; Acrylic acid chloride; Acrylic chloride; Acryloyl chloride→N-[5-[(4-[4-[(dimethylamino)methyl]-3-phenyl-1H-pyrazol-1-yl]pyrimidin-2-yl)amino]-4-methoxy-2-(morpholin-4-yl)phenyl]prop-2-enamide
2,6-Dichloronicotinonitrile→2,6-Dichloronicotinamide→2,6-Dichloropyridine-3-carboxylic acid→(3-Phenoxyphenyl)boronic acid→4,4,5,5-Tetramethyl-2-(3-phenoxyphenyl)-1,3,2-dioxaborolane→6-Chloro-2-(4-phenoxyphenyl)pyridine-3-carboxamide→N-Boc-1,2,5,6-tetrahydropyridine-4-boronic acid pinacol ester→tert-Butyl 5-carbamoyl-6-(4-phenoxyphenyl)-3',6'-dihydro[2,4'-bipyridine]-1'(2'H)-carboxylate→tert-Butyl 4-[5-carbamoyl-6-(4-phenoxyphenyl)pyridin-2-yl]piperidine-1-carboxylate→2-(4-Phenoxyphenyl)-6-(piperidin-4-yl)pyridine-3-carboxamide→2-(4-Phenoxyphenyl)-6-(piperidin-4-yl)pyridine-3-carboxamide hydrogen chloride→Acryloyl chloride
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | 3-phenyl-1H-pyrazole-4-carbaldehyde Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | 4-Chloro-2-(methylsulfonyl)pyrimidine Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | 4-chloro-N-(2-methoxy-4-morpholino-5-nitrophenyl)pyrimidin-2-amine Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | 1-(2-((2-methoxy-4-morpholino-5-nitrophenyl)amino)pyrimidin-4-yl)-3-phenyl-1H-pyrazole-4-carbaldehyde Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | 4-(4-((dimethylamino)methyl)-3-phenyl-1H-pyrazol-1-yl)-N-(2-methoxy-4-morpholino-5-nitrophenyl)pyrimidin-2-amine Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | N1-(4-(4-((dimethylamino)methyl)-3-phenyl-1H-pyrazol-1-yl)pyrimidin-2-yl)-6-methoxy-4-morpholinobenzene-1,3-diamine Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | 4-fluoro-2-Methoxy-5-nitroaniline Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | 3-(2-chloropyriMidin-4-yl)-1-Methylindole Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | N-(4-fluoro-2-Methoxy-5-nitrophenyl)-4-(1-Methylindol-3-yl)pyriMidin-2-aMine Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | 1,4-BenzenediaMine, N1-[2-(diMethylaMino)ethyl]-5-Methoxy-N1-Methyl-N4-[4-(1-Methyl-1H-indol-3-yl)-2-pyriMidinyl]-2-nitro- Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | N1-[2-(diMethylaMino)ethyl]-5-Methoxy-N1-Methyl-N4-[4-(1-Methyl-1H-indol-3-yl)-2-pyriMidinyl]benzene-1,2,4-triamine Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | N,N,N'-Trimethylethylenediamine Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | 4-Methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | N-(3-Chloropropyl)morpholine Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | 5-hydroxy-4-methoxy-2-nitrobenzoic acid ethyl ester Pharmaceutical Intermediates | On request | On request | On request | — |
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