← Back to patent-cliff list
CAS 824-94-2
1-(chloromethyl)-4-methoxybenzene
Codes: EFAV-010, Lopix-016
Application context (from source-drug indications)
HIV infectionEfavirenz/Lamivudine/Tenofovir Disoproxil FumarateHIV infectionEfavirenzCreutzfeldt-Jakob diseaseEfavirenzAlzheimer's diseaseEfavirenzPancreatic cancerEfavirenzProstate cancerEfavirenzNon-Hodgkin lymphomaEfavirenzPruritusMaralixibat Chloride进行性家族性肝内胆汁淤积症Maralixibat ChlorideAlagille综合征Maralixibat Chloride胆汁淤积Maralixibat ChlorideLiver diseaseMaralixibat Chloride肝内胆汁淤积Maralixibat Chloride
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Efavirenz/Lamivudine/Tenofovir Disoproxil Fumarate | Tier C — Watch / trade | - |
| Efavirenz | Tier B — Position early | - |
| Maralixibat Chloride | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
N-(4-chlorophenyl)pivalamide→1-(2-amino-5-chlorophenyl)-2,2,2-trifluoroethanone→ethynylcyclopropane→1-(chloromethyl)-4-methoxybenzene→1-(5-chloro-2-((4-methoxybenzyl)amino)phenyl)-2,2,2-trifluoroethanone→(1R,2S)-1-phenyl-2-(pyrrolidin-1-yl)propan-1-ol→(S)-2-(5-chloro-2-((4-methoxybenzyl)amino)phenyl)-4-cyclopropyl-1,1,1-trifluorobut-3-yn-2-ol→(S)-6-chloro-4-(cyclopropylethynyl)-1-(4-methoxybenzyl)-4-(trifluoromethyl)-1H-benzo[d][1,3]oxazin-2(4H)-one
N-(4-chlorophenyl)pivalamide→1-(2-amino-5-chlorophenyl)-2,2,2-trifluoroethanone→ethynylcyclopropane→1-(chloromethyl)-4-methoxybenzene→1-(5-chloro-2-((4-methoxybenzyl)amino)phenyl)-2,2,2-trifluoroethanone→(1R,2S)-1-phenyl-2-(pyrrolidin-1-yl)propan-1-ol→(S)-2-(5-chloro-2-((4-methoxybenzyl)amino)phenyl)-4-cyclopropyl-1,1,1-trifluorobut-3-yn-2-ol→(S)-6-chloro-4-(cyclopropylethynyl)-1-(4-methoxybenzyl)-4-(trifluoromethyl)-1H-benzo[d][1,3]oxazin-2(4H)-one
diethyl 2,2-dibutylmalonate→2,2-dibutylpropane-1,3-diol→1,3,2-Dioxathiane, 5,5-dibutyl-, 2-oxide→1,3,2-Dioxathiane, 5,5-dibutyl-, 2,2-dioxide→4-fluoro-2-(4-methoxybenzyl)benzenethiol→2-butyl-2-((4-fluoro-2-(4-methoxybenzyl)phenylthio)methyl)hexan-1-ol→2-butyl-2-((4-fluoro-2-(4-methoxybenzyl)phenylsulfinyl)methyl)hexan-1-ol→2-butyl-2-((4-fluoro-2-(4-methoxybenzyl)phenylsulfinyl)methyl)hexanal→1-Benzothiepin-4-ol, 3,3-dibutyl-7-fluoro-2,3,4,5-tetrahydro-5-(4-methoxyphenyl)-, 1-oxide, (4R,5R)→1-Benzothiepin-4-ol, 3,3-dibutyl-7-fluoro-2,3,4,5-tetrahydro-5-(4-methoxyphenyl)-, 1,1-dioxide, (4R,5R)→1-Benzothiepin-4-ol, 3,3-dibutyl-7-(dimethylamino)-2,3,4,5-tetrahydro-5-(4-methoxyphenyl)-, 1,1-dioxide, (4R,5R)-rel→1-Benzothiepin-4-ol, 3,3-dibutyl-7-(dimethylamino)-2,3,4,5-tetrahydro-5-(4-hydroxyphenyl)-, 1,1-dioxide, (4R,5R)→1,4-bis(chloromethyl)benzene→1-Benzothiepin-4-ol, 3,3-dibutyl-5-[4-[[4-(chloromethyl)phenyl]methoxy]phenyl]-7-(dimethylamino)-2,3,4,5-tetrahydro-, 1,1-dioxide, (4R,5R)→4-fluorophenol→1-(chloromethyl)-4-methoxybenzene→4-fluoro-2-(4-methoxybenzyl)phenol→dimethylcarbamothioic chloride→O-4-fluoro-2-(4-methoxybenzyl)phenyl dimethylcarbamothioate
Intermediates available on this site
No listed intermediates for this target yet — send an RFQ directly and it will enter our matching pool.
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.