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CAS 38041-19-9
tetrahydro-2H-pyran-4-amine
Codes: Zeprumetostat-006
Application context (from source-drug indications)
Peripheral T-cell lymphomaZeprumetostatLymphomaZeprumetostatT-cell lymphomaZeprumetostatMyelodysplastic syndromeZeprumetostatAcute lymphoblastic leukaemiaZeprumetostatAcute myeloid leukaemiaZeprumetostat
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Zeprumetostat | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-ethylbenzoic acid→2-ethyl-6-iodobenzoic acid→3,5-dibromo-2-ethyl-6-iodobenzoic acid→1-(prop-2-yn-1-yl)piperidine→6-bromo-5-ethyl-2-(piperidin-1-ylmethyl)benzofuran-4-carboxylic acid hydrogen chloride→tetrahydro-2H-pyran-4-amine→5-ethyl-2-(piperidin-1-ylmethyl)-6-((tetrahydro-2H-pyran-4-yl)amino)benzofuran-4-carboxylic acid→5-ethyl-6-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-(piperidin-1-ylmethyl)benzofuran-4-carboxylic acid→3-(aminomethyl)-4,6-dimethylpiperidin-2-one hydrogen chloride
6-bromo-5-ethyl-2-(piperidin-1-ylmethyl)benzofuran-4-carboxylic acid hydrogen chloride→3-(aminomethyl)-4,6-dimethylpyridin-2(1H)-one→6-bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-ethyl-2-(piperidin-1-ylmethyl)benzofuran-4-carboxamide→tetrahydro-2H-pyran-4-amine→N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-ethyl-2-(piperidin-1-ylmethyl)-6-((tetrahydro-2H-pyran-4-yl)amino)benzofuran-4-carboxamide
Intermediates available on this site
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