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CAS 38496-18-3
2,6-Dichloronicotinic acid2,6-Dichloropyridine-3-carboxylic acid
Codes: (I)1225102-2-a, (III)965082-1-a
Application context (from source-drug indications)
Non-small cell lung cancerFulzerasibColorectal cancerFulzerasibSolid tumourFulzerasibMarginal zone B-cell lymphomaOrelabrutinibMantle cell lymphomaOrelabrutinibChronic lymphocytic leukaemiaOrelabrutinibImmune thrombocytopenic purpuraOrelabrutinibSystemic lupus erythematosusOrelabrutinibMultiple sclerosisOrelabrutinib
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Fulzerasib | Tier C — Watch / trade | - |
| Orelabrutinib | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2,6-Dichloronicotinic acid→2-Isopropyl-4-methylpyridin-3-amine→6-Chloro-2-[(2-isopropyl-4-methyl-3-pyridyl)amino]pyridine-3-carboxylic acid→5,6-Dichloro-2-[(2-isopropyl-4-methyl-3-pyridyl)amino]pyridine-3-carboxylic acid→5,6-Dichloro-2-[[4-methyl-2-(propan-2-yl)pyridin-3-yl]amino]pyridine-3-carbonyl chloride→3-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-oxopropanoic acid→(alphaR)-alpha-Methyl-3,5-bis(trifluoromethyl)benzenemethanol→2,2-Dimethyl-1,3-dioxane-4,6-dione→3-Oxo-3-[(1S)-1-phenylethoxy]propanoic acid→(1S)-Methyl phenyl carbinol→(1S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethyl 3-(5,6-dichloro-2-[[4-methyl-2-(propan-2-yl)pyridin-3-yl]amino]pyridin-3-yl)-3-oxopropanoate→(1S)-1-Phenylethyl 3-(5,6-dichloro-2-[[4-methyl-2-(propan-2-yl)pyridin-3-yl]amino]pyridin-3-yl)-3-oxopropanoate→6,7-Dichloro-4-hydroxy-1-(2-isopropyl-4-methyl-3-pyridyl)-1,8-naphthyridin-2-one→3-[(1R,2S,5R)-2-Isopropyl-5-methylcyclohexoxy]-3-oxo-propanoic acid→(-)-(1R-(1-alpha,2-beta,5-alpha))-5-Methyl-2-(1-methylethyl)cyclohexanol→(1R,2S,5R)-5-Methyl-2-(propan-2-yl)cyclohexyl 3-(5,6-dichloro-2-[[4-methyl-2-(propan-2-yl)pyridin-3-yl]amino]pyridin-3-yl)-3-oxopropanoate
2,6-Dichloronicotinonitrile→2,6-Dichloronicotinamide→2,6-Dichloropyridine-3-carboxylic acid→(3-Phenoxyphenyl)boronic acid→4,4,5,5-Tetramethyl-2-(3-phenoxyphenyl)-1,3,2-dioxaborolane→6-Chloro-2-(4-phenoxyphenyl)pyridine-3-carboxamide→N-Boc-1,2,5,6-tetrahydropyridine-4-boronic acid pinacol ester→tert-Butyl 5-carbamoyl-6-(4-phenoxyphenyl)-3',6'-dihydro[2,4'-bipyridine]-1'(2'H)-carboxylate→tert-Butyl 4-[5-carbamoyl-6-(4-phenoxyphenyl)pyridin-2-yl]piperidine-1-carboxylate→2-(4-Phenoxyphenyl)-6-(piperidin-4-yl)pyridine-3-carboxamide→2-(4-Phenoxyphenyl)-6-(piperidin-4-yl)pyridine-3-carboxamide hydrogen chloride→Acryloyl chloride
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