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CAS 98-56-6
1-Chloro-4-(trifluoromethyl)benzene
Codes: (VII)236036-3-a, (VI)236036-4-a, (IX)236036-8-a, (VI)263642-1-a, (VIII)263642-2-a, (VI)263642-6-a, (VII)263642-7-a, (XI)263642-13-a, (V)131699-11-a
Application context (from source-drug indications)
分离性焦虑S-fluoxetineAnxietyS-fluoxetineAnxiety disorderS-fluoxetine分离性焦虑R-fluoxetineAnxietyR-fluoxetineAnxiety disorderR-fluoxetine
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| S-fluoxetine | Tier C — Watch / trade | - |
| R-fluoxetine | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
Ethyl (3S)-3-hydroxy-3-phenylpropanoate→1-Phenylpropane-1,3-diol→1-Phenyl-3-(4-toluenesulphonyloxy)propan-1-ol→(1S)-3-{[(4-methylbenzene)sulfonyl]oxy}-1-phenylpropan-1-ol→3-{[(4-methylbenzene)sulfonyl]oxy}-1-phenylpropan-1-one→(1S)-3-(Methylamino)-1-phenylpropan-1-ol→1-Chloro-4-(trifluoromethyl)benzene
Benzaldehyde→Ethynamine→3-Hydroxy-3-phenylpropanenitrile→3-Amino-1-phenylpropan-1-ol→(1S)-3-Amino-1-phenylpropan-1-ol→Carbonochloridic acid methyl ester→Methyl [(3S)-3-hydroxy-3-phenylpropyl]carbamate→(1S)-3-(Methylamino)-1-phenylpropan-1-ol→1-Chloro-4-(trifluoromethyl)benzene→(3S)-3-Phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine hydrochloride→Methyl [(3S)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl]carbamate
3-Benzoylpropanoic acid→Methyl 4-oxo-4-phenylbutanoate→(5S)-5-phenyloxolan-2-one→(4S)-4-hydroxy-4-phenylbutanamide→(6S)-6-phenyl-1,3-oxazinan-2-one→(6S)-3-methyl-6-phenyl-1,3-oxazinan-2-one→(1S)-3-(Methylamino)-1-phenylpropan-1-ol→1-Chloro-4-(trifluoromethyl)benzene
Ethenylbenzene→(1S)-1-phenylethane-1,2-diol→(1S)-2-{[(4-methylbenzene)sulfonyl]oxy}-1-phenylethan-1-ol→(3R)-3-Hydroxy-3-phenylpropanenitrile→(1R)-3-Amino-1-phenylpropan-1-ol→1-Chloro-4-(trifluoromethyl)benzene→3(R)-Phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine→Carbonochloridic acid methyl ester→Methyl [(3R)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl]carbamate
3-Oxo-3-phenylpropanenitrile→(3R)-3-Hydroxy-3-phenylpropanenitrile→3-Hydroxy-3-phenylpropanenitrile→(1R)-3-Amino-1-phenylpropan-1-ol→Carbonochloridic acid ethyl ester→Carbonochloridic acid methyl ester→Ethyl [(3R)-3-hydroxy-3-phenylpropyl]carbamate→Methyl [(3R)-3-hydroxy-3-phenylpropyl]carbamate→(1R)-3-(Methylamino)-1-phenylpropan-1-ol→1-Chloro-4-(trifluoromethyl)benzene→(3R)-3-Phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine hydrochloride→Methyl [(3R)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl]carbamate→Benzaldehyde→Ethynamine
3-Phenyl-2(E)-propenal→1,1-Diphenylmethylamine→1,1-Diphenyl-N-[(1E,2E)-3-phenylprop-2-en-1-ylidene]methanamine→4,4,4',4',5,5,5',5'-Octamethyl-2,2'-bi-1,3,2-dioxaborolane→1,1-Diphenyl-N-[(1E)-3-phenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propylidene]methanamine→1,1-Diphenyl-N-[(1E,3R)-3-phenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propylidene]methanamine→Aminomethane→N-[(1E)-3-Phenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propylidene]methanamine→N-[(1E,3R)-3-Phenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propylidene]methanamine→N-Methyl-3-phenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propan-1-amine→(3R)-N-Methyl-3-phenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propan-1-amine→(+/-)-n-Methyl-3-hydroxy-3-phenylpropylamine→(1R)-3-(Methylamino)-1-phenylpropan-1-ol→Sodium 3-(methylamino)-1-phenylpropan-1-olate→Sodium (1R)-3-(methylamino)-1-phenylpropan-1-olate→1-Chloro-4-(trifluoromethyl)benzene→(+/-)-N-Methyl-3-phenyl-[3-[4-(trifluoromethyl)phenoxy]propylamine]
3-Benzoylpropanoic acid→(5R)-5-Phenyloxolan-2-one→(4R)-4-Hydroxy-4-phenylbutanamide→(6R)-6-Phenyl-1,3-oxazinan-2-one→1-Chloro-4-(trifluoromethyl)benzene→(3R)-N-Methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine hydrogen chloride
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