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Metabolic & GLP-1
114 · drugs68 · with routes45 · with on-sale intermediates
114 patent-cliff drugs in Metabolic & GLP-1 (classified by indication keywords and explicit molecule lists from our structured data), 68 with recorded synthesis routes and 45 with on-sale intermediates. Every "Available" badge links to real listings for RFQ.
| Drug | Tier | Expiry | Indications | Routes | CAS count | Available |
|---|---|---|---|---|---|---|
| Finerenone | C · Watch | 2030 | Systolic heart failure, Diastolic heart failure, Heart failure | 35 | 96 | Available ×96 |
| Ertugliflozin | C · Watch | - | Type 2 diabetes | 4 | 48 | Available ×48 |
| Empagliflozin | A · Act now | 2028 | Chronic renal impairment, Heart failure, Type 2 diabetes | 3 | 24 | Available ×24 |
| Linagliptin | C · Watch | 2029 | Type 2 diabetes | 4 | 21 | Available ×21 |
| Lifitegrast | C · Watch | - | Dry eye disease, Dry eye syndrome | 1 | 20 | Available ×20 |
| Mirogabalin besilate | C · Watch | 2030 | Diabetic neuropathy, Postherpetic neuralgia, Peripheral nervous system disorder | 2 | 14 | Available ×14 |
| Sotagliflozin | C · Watch | 2032 | Type 2 diabetes, Chronic renal impairment, Heart failure | 1 | 14 | Available ×14 |
| Vericiguat | C · Watch | - | Heart failure | 1 | 12 | Available ×12 |
| Tenapanor hydrochloride | C · Watch | - | Hyperphosphataemia, Chronic renal impairment, Constipation | 1 | 10 | Available ×10 |
| Alogliptin Benzoate | C · Watch | - | Type 2 diabetes | 4 | 24 | Available ×9 |
| Nebivolol Hydrochloride | C · Watch | - | Hypertension | 1 | 8 | Available ×8 |
| Dapagliflozin Propanediol/Metformin Hydrochloride | A · Act now | 2030 | Type 2 diabetes | 4 | 16 | Available ×6 |
| Sitagliptin Phosphate Monohydrate/Ipragliflozin L-Proline | C · Watch | - | Type 2 diabetes | 4 | 16 | Available ×6 |
| Dapagliflozin Propanediol Monohydrate | B · Position early | - | Chronic renal impairment, Heart failure, Kidney disease | 4 | 16 | Available ×6 |
| Ipragliflozin L-Proline | C · Watch | - | Type 2 diabetes, Type 1 diabetes | 4 | 16 | Available ×6 |
| Alogliptin Benzoate/Pioglitazone Hydrochloride | C · Watch | - | Type 2 diabetes | 5 | 28 | Available ×5 |
| Pioglitazone Hydrochloride | B · Position early | - | Type 2 diabetes | 5 | 28 | Available ×5 |
| Dapagliflozin Propanediol Monohydrate/Saxagliptin Hydrochloride | C · Watch | - | Type 2 diabetes | 4 | 48 | Available ×5 |
| Saxagliptin Hydrate | B · Position early | - | Type 2 diabetes | 4 | 48 | Available ×5 |
| Canagliflozin/Metformin Hydrochloride | B · Position early | 2029 | End-stage renal disease, Cardiac and vascular disorders, Abdominal aortic aneurysm | 3 | 19 | Available ×5 |
| Canagliflozin Hemihydrate | C · Watch | - | Type 2 diabetes, Diabetic nephropathy | 3 | 19 | Available ×5 |
| Enalapril Maleate | C · Watch | - | Heart failure, Hypertension, Myocardial infarction | 14 | 69 | Available ×4 |
| Atorvastatin Calcium Hydrate/Metformin Hydrochloride | C · Watch | - | Type 2 diabetes, Hyperlipidaemia | 5 | 55 | Available ×4 |
| Atorvastatin Calcium Hydrate | B · Position early | - | Hyperlipoproteinaemia type III, Hyperlipidaemia, Heterozygous familial hypercholesterolaemia | 5 | 55 | Available ×4 |
| Vildagliptin | B · Position early | - | Type 2 diabetes | 6 | 25 | Available ×3 |
| Mitiglinide | C · Watch | - | Type 2 diabetes | 5 | 29 | Available ×3 |
| Orlistat | C · Watch | - | Obesity | 5 | 80 | Available ×3 |
| Trelagliptin Succinate | C · Watch | - | Type 2 diabetes | 3 | 16 | Available ×3 |
| Astaxanthin | C · Watch | - | 营养失调 | 14 | 30 | Available ×2 |
| Telmisartan | B · Position early | - | Hypertension | 5 | 35 | Available ×2 |
| Irbesartan | B · Position early | - | Oesophageal disease, Hypertension, Diabetic nephropathy | 5 | 29 | Available ×2 |
| Pregabalin | B · Position early | - | Fibromyalgia, Seizure, Postherpetic neuralgia | 5 | 28 | Available ×2 |
| Vorolanib | C · Watch | - | Renal cell carcinoma | 1 | 6 | Available ×2 |
| Tirzepatide | B · Position early | 2036 | Obstructive sleep apnoea syndrome, Obesity, Overweight | 9 | 1 | Available ×1 |
| Desvenlafaxine Succinate Hydrate | C · Watch | - | Depressive disorder, Major depressive disorder | 6 | 22 | Available ×1 |
| Donepezil Hydrochloride | B · Position early | - | Lewy body dementia, Alzheimer's disease, Dementia | 5 | 20 | Available ×1 |
| Bosentan Hydrate | B · Position early | - | 溃疡, Pulmonary arterial hypertension, Pulmonary hypertension | 5 | 18 | Available ×1 |
| Entacapone | C · Watch | - | Parkinson's disease | 5 | 16 | Available ×1 |
| Alprazolam | C · Watch | - | Anxiety disorder, Panic disorder | 3 | 12 | Available ×1 |
| Inavolisib | C · Watch | - | Breast cancer, Metastatic breast cancer | 2 | 19 | Available ×1 |
| Amlodipine Maleate | C · Watch | - | Hypertension, Angina pectoris | 2 | 10 | Available ×1 |
| Fultagliptin Benzoate | C · Watch | - | Type 2 diabetes | 1 | 10 | Available ×1 |
| Retagliptin Phosphate | C · Watch | - | Type 2 diabetes | 1 | 13 | Available ×1 |
| Henagliflozin Proline | C · Watch | - | Type 2 diabetes | 1 | 15 | Available ×1 |
| Chiglitazar Sodium | C · Watch | - | Type 2 diabetes | 1 | 5 | Available ×1 |
| Ramipril | C · Watch | - | Hypertension, Nephropathy, Myocardial infarction | 15 | 38 | - |
| Setmelanotide Acetate | C · Watch | - | 下丘脑肥胖, 巴德特-别德尔综合征, Obesity | 7 | 29 | - |
| Azilsartan | C · Watch | - | Hypertension | 6 | 20 | - |
| Formoterol Fumarate | C · Watch | - | Chronic obstructive pulmonary disease, Emphysema, Asthma | 6 | 6 | - |
| Olmesartan Medoxomil | B · Position early | - | Hypertension | 5 | 19 | - |
| Atazanavir Sulfate | B · Position early | - | HIV infection | 5 | 35 | - |
| Fondaparinux Sodium | C · Watch | - | Pulmonary embolism, Venous thrombosis, Myocardial infarction | 5 | 43 | - |
| Bremelanotide | C · Watch | - | Psychogenic sexual dysfunction | 4 | 1 | - |
| Topiroxostat | C · Watch | - | Hyperuricaemia, Gout | 4 | 13 | - |
| Levothyroxine Sodium | B · Position early | - | Coma, 粘液性水肿昏迷, Hypothyroidism | 4 | 14 | - |
| Cetilistat | C · Watch | - | Obesity | 3 | 9 | - |
| Fenofibrate | C · Watch | - | Hypercholesterolaemia, Hypertriglyceridaemia | 3 | 5 | - |
| Chlorthalidone | C · Watch | - | Hypertension, Oedema, Diabetes insipidus | 2 | 4 | - |
| Risedronate Sodium Hydrate | C · Watch | - | Paget's disease, Postmenopausal osteoporosis, Osteoporosis | 2 | 3 | - |
| Levoketoconazole | C · Watch | - | Cushing's syndrome | 2 | 11 | - |
| Tirbanibulin | C · Watch | - | Actinic keratosis | 2 | 12 | - |
| PEG-Loxenatide | C · Watch | - | Type 2 diabetes | 1 | 2 | - |
| Lobeglitazone Sulfate | C · Watch | - | Type 2 diabetes | 1 | 9 | - |
| Misoprostol | C · Watch | - | Termination of pregnancy, Duodenal ulcer, Gastric ulcer | 1 | 5 | - |
| Naloxone Hydrochloride | C · Watch | - | Opioid dependence, 中毒 | 1 | 8 | - |
| Cofrogliptin | C · Watch | - | Type 2 diabetes | 1 | 8 | - |
| Elafibranor | C · Watch | - | Sclerosing cholangitis, Biliary cirrhosis | 1 | 5 | - |
| Elismetrep | C · Watch | - | Migraine, 糖尿病周围神经病变, Hot flushes | 1 | 9 | - |
| Glucagon intranasal (Eli Lilly/Locemia Solutions) | C · Watch | - | Hypoglycaemia | - | - | - |
| Angiotensin II | C · Watch | - | Hypotension, Shock | - | - | - |
| Sitagliptin/Ertugliflozin | C · Watch | - | Type 2 diabetes | - | - | - |
| Metformin Hydrochloride/Ertugliflozin | C · Watch | - | Type 2 diabetes | - | - | - |
| Iron Isomaltoside | C · Watch | - | Iron deficiency anaemia | - | - | - |
| Linagliptin/Empagliflozin | C · Watch | - | Cardiac and vascular disorders, Type 2 diabetes | - | - | - |
| Gemigliptin L-tartrate Sesquihydrate/Metformin Hydrochloride | C · Watch | - | Type 2 diabetes | - | - | - |
| Metformin acetate | C · Watch | - | Obesity, Diabetes | - | - | - |
| Linagliptin/Metformin Hydrochloride | B · Position early | - | Type 2 diabetes | - | - | - |
| Rosilitazone Tartrate | C · Watch | - | Type 2 diabetes | - | - | - |
| Bupropion hydrobromide | C · Watch | - | Seasonal affective disorder, Major depressive disorder | - | - | - |
| Vildagliptin/Metformin Hydrochloride | C · Watch | - | Type 2 diabetes | - | - | - |
| Semaglutide | A · Act now | 2031 | Overweight, Obesity, Type 2 diabetes | - | - | - |
| Crisugabalin Besilate | C · Watch | - | Postherpetic neuralgia, Diabetic neuropathy | - | - | - |
| Enavogliflozin/Metformin Hydrochloride | C · Watch | - | Type 2 diabetes | - | - | - |
| Dapagliflozin Propanediol Hydrate/Sitagliptin Phosphate Hydrate | C · Watch | - | Type 2 diabetes | - | - | - |
| Glimepiride/Dapagliflozin Propanediol Monohydrate | C · Watch | - | Type 2 diabetes | - | - | - |
| Triamcinolone Acetonide Suprachoroidal Injectable Suspension(Arctic Vision) | C · Watch | - | 黄斑水肿, 葡萄膜炎 | - | - | - |
| Sitagliptin Tartrate | C · Watch | - | Non-alcoholic steatohepatitis, Diabetic nephropathy, Type 1 diabetes | - | - | - |
| Diperoxochloric acid | C · Watch | - | 糖尿病足溃疡 | - | - | - |
| Lidocaine Cataplasms(Beijing Tide Pharma) | C · Watch | - | 糖尿病周围神经性疼痛, Postherpetic neuralgia | - | - | - |
| Repaglinide/Metformin Hydrochloride | C · Watch | - | Type 2 diabetes | - | - | - |
| Secretin | C · Watch | - | 胰腺疾病, Contrast imaging, Diagnostic agent | - | - | - |
| Glucosamine Hydrochloride | C · Watch | - | Osteoarthritis | - | - | - |
| Glyburide/Metformin Hydrochloride | C · Watch | - | Type 2 diabetes | - | - | - |
| Colesevelam Hydrochloride | C · Watch | - | Hypercholesterolaemia, Hyperlipoproteinaemia type II, Type 2 diabetes | - | - | - |
| Tetrachlorodecaoxide | C · Watch | - | Allergic rhinitis, Inflammatory disease | - | - | - |
| AD-233 | C · Watch | - | Type 2 diabetes | - | - | - |
| AZD-6234 | C · Watch | - | Overweight, Obesity, Type 2 diabetes | - | - | - |
| GUB-014295 | C · Watch | - | Overweight, Obesity | - | - | - |
| BI-3034701 | C · Watch | - | Overweight, Obesity | - | - | - |
| UBT-251 | C · Watch | - | Obesity, Obstructive sleep apnoea syndrome, Type 2 diabetes | - | - | - |
| ERX-1000 | C · Watch | - | Overweight, Obesity | - | - | - |
| YJ001 | C · Watch | - | 糖尿病周围神经性疼痛, 糖尿病周围神经病变, Diabetic neuropathy | - | - | - |
| Enicepatide | C · Watch | - | Overweight, Obesity, Type 2 diabetes | - | - | - |
| HRS-1780 | C · Watch | - | Hypertension, Chronic renal impairment, 醛固酮增多症 | - | - | - |
| ALN-2232 | C · Watch | - | Obesity | - | - | - |
| ATR-258 | C · Watch | - | Overweight, Obesity, Type 2 diabetes | - | - | - |
| LY-4065967 | C · Watch | - | Low back pain, Chronic pain, Knee arthritis | - | - | - |
| MOTS-c | C · Watch | - | Overweight, Obesity, 糖尿病前期 | - | - | - |
| MDR-001 | C · Watch | - | Overweight, Obesity, Hypertension | - | - | - |
| Kamuvudine-9 | C · Watch | - | Diabetic macular oedema, 甲状腺相关性眼病 | - | - | - |
| BAFA | C · Watch | - | 钙代谢障碍 | - | - | - |
| ACCG-2671 | C · Watch | - | Obesity | - | - | - |
| ECC-4703 | C · Watch | - | Obesity, 体重, Non-alcoholic steatohepatitis | - | - | - |
| Linafexor | C · Watch | - | Sclerosing cholangitis, Biliary cirrhosis, Non-alcoholic steatohepatitis | - | - | - |
Frequently asked questions
Which patent-cliff drugs in Metabolic & GLP-1 are worth tracking?
114 drugs related to Metabolic & GLP-1 are tracked on this site, 68 of them with recorded synthesis routes. See the table above and open each drug profile for routes and intermediates.
Where can I source Metabolic & GLP-1 intermediates?
Key intermediates of 45 drugs in this table are available through the Unibest supply network; for the rest, submit an RFQ per CAS on the intermediate profile pages.
Where can I check patent expiry for these drugs?
Each drug profile shows the public expiry year; yearly overviews are available at /patent-cliff/expires/<year>.
Source: cross-verified structured fields · Classification: indication keywords + explicit molecule lists · 2026-09-29