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Oncology & Hematology
239 · drugs135 · with routes89 · with on-sale intermediates
239 patent-cliff drugs in Oncology & Hematology (classified by indication keywords and explicit molecule lists from our structured data), 135 with recorded synthesis routes and 89 with on-sale intermediates. Every "Available" badge links to real listings for RFQ.
| Drug | Tier | Expiry | Indications | Routes | CAS count | Available |
|---|---|---|---|---|---|---|
| Palbociclib | A · Act now | 2027 | Breast cancer | 5 | 52 | Available ×52 |
| Anidulafungin | C · Watch | - | Candidiasis, Candidaemia | 11 | 41 | Available ×41 |
| Lazertinib Mesylate | C · Watch | - | Non-small cell lung cancer | 5 | 32 | Available ×32 |
| Axitinib | B · Position early | - | Renal cell carcinoma | 5 | 31 | Available ×31 |
| Alectinib Hydrochloride | B · Position early | 2030 | Non-small cell lung cancer, Lung cancer | 3 | 30 | Available ×30 |
| Crizotinib | C · Watch | - | Primary cutaneous anaplastic large cell lymphoma, Anaplastic large cell lymphoma, Non-small cell lung cancer | 5 | 29 | Available ×29 |
| Osimertinib Mesylate | A · Act now | 2031 | Non-small cell lung cancer | 4 | 29 | Available ×29 |
| Sunitinib Malate | B · Position early | - | Pancreatic neuroendocrine tumour, Renal cell carcinoma, Gastrointestinal stromal tumour | 5 | 27 | Available ×27 |
| Sofosbuvir | B · Position early | - | Chronic hepatitis C, Hepatitis C | 3 | 26 | Available ×26 |
| Nintedanib Esylate | B · Position early | - | Systemic sclerosis-associated interstitial lung disease, Idiopathic pulmonary fibrosis, Non-small cell lung cancer | 4 | 25 | Available ×25 |
| Febuxostat | C · Watch | - | Hyperuricaemia, Gout | 4 | 25 | Available ×25 |
| Cabozantinib S-malate | B · Position early | 2029 | Neuroendocrine tumour, Pancreatic neuroendocrine tumour, Renal cell carcinoma | 3 | 21 | Available ×21 |
| Apalutamide | A · Act now | 2030 | Castration-resistant prostate cancer, Prostate cancer | 2 | 20 | Available ×20 |
| Lenvatinib Mesilate | A · Act now | 2028 | Renal cell carcinoma, Endometrial cancer, Hepatocellular carcinoma | 3 | 18 | Available ×18 |
| Paclitaxel/Encequidar mesylate | C · Watch | - | Breast cancer, Adenocarcinoma | 112 | 557 | Available ×17 |
| Paclitaxel | B · Position early | - | Pancreatic cancer, Non-small cell lung cancer, Hodgkin's disease | 112 | 557 | Available ×17 |
| Capmatinib Hydrochloride | C · Watch | 2032 | Non-small cell lung cancer | 1 | 16 | Available ×16 |
| Abemaciclib | A · Act now | 2029 | Breast cancer | 2 | 15 | Available ×15 |
| Ribociclib Succinate | A · Act now | 2029 | Breast cancer | 1 | 14 | Available ×14 |
| Entrectinib | C · Watch | 2030 | Solid tumour, Non-small cell lung cancer | 1 | 14 | Available ×14 |
| Olaparib | A · Act now | 2028 | Endometrial cancer, Castration-resistant prostate cancer, Prostate cancer | 2 | 13 | Available ×13 |
| Dabrafenib Mesylate | B · Position early | 2029 | Thyroid cancer, Colorectal cancer, Glioma | 2 | 12 | Available ×12 |
| Relugolix | C · Watch | 2031 | Prostate cancer, Leiomyoma | 1 | 12 | Available ×12 |
| Vericiguat | C · Watch | - | Heart failure | 1 | 12 | Available ×12 |
| Tucatinib | C · Watch | 2030 | Breast cancer, Colorectal cancer | 1 | 10 | Available ×10 |
| Darolutamide | B · Position early | 2031 | Hormone-sensitive prostate cancer, Castration-sensitive prostate cancer, Prostate cancer | 1 | 9 | Available ×9 |
| Pazopanib Hydrochloride | C · Watch | - | Renal cell carcinoma, Sarcoma, Soft tissue neoplasm | 1 | 9 | Available ×9 |
| Nebivolol Hydrochloride | C · Watch | - | Hypertension | 1 | 8 | Available ×8 |
| Fulzerasib | C · Watch | - | Non-small cell lung cancer | 4 | 12 | Available ×6 |
| Iruplinalkib | C · Watch | - | Non-small cell lung cancer | 4 | 12 | Available ×6 |
| Trametinib | C · Watch | 2029 | Thyroid cancer, Glioma, Hairy cell leukaemia | 1 | 13 | Available ×6 |
| Ixabepilone | C · Watch | - | Breast cancer | 5 | 84 | Available ×5 |
| Pioglitazone Hydrochloride | B · Position early | - | Type 2 diabetes | 5 | 28 | Available ×5 |
| Canagliflozin Hemihydrate | C · Watch | - | Type 2 diabetes, Diabetic nephropathy | 3 | 19 | Available ×5 |
| Fezolinetant | C · Watch | - | Vasomotor symptoms, Hot flushes | 1 | 5 | Available ×5 |
| Pralsetinib | C · Watch | 2031 | Non-small cell lung cancer, Thyroid cancer, Medullary thyroid cancer | 7 | 41 | Available ×4 |
| Afatinib Dimaleate | C · Watch | - | Non-small cell lung cancer | 4 | 33 | Available ×4 |
| Icotinib Hydrochloride | C · Watch | - | Non-small cell lung cancer | 4 | 23 | Available ×4 |
| Dalpiciclib Isethionate | C · Watch | - | Breast cancer, Metastatic breast cancer | 4 | 20 | Available ×4 |
| Selpercatinib | C · Watch | 2032 | Solid tumour, Medullary thyroid cancer, Non-small cell lung cancer | 3 | 26 | Available ×4 |
| Ensartinib Hydrochloride | C · Watch | - | Non-small cell lung cancer | 1 | 10 | Available ×4 |
| Docetaxel polymeric micelle (Samyang Biopharmaceuticals) | C · Watch | - | Bladder cancer, Head and neck cancer | 37 | 156 | Available ×3 |
| Docetaxel （Beihai） | C · Watch | - | Non-small cell lung cancer, Prostate cancer, Castration-resistant prostate cancer | 37 | 157 | Available ×3 |
| Conjugated Estrogens/Bazedoxifene Acetate | C · Watch | - | Oestrogen deficiency syndrome, Osteoporosis, Vasomotor symptoms | 5 | 28 | Available ×3 |
| Bazedoxifene Acetate | C · Watch | - | Postmenopausal osteoporosis | 5 | 28 | Available ×3 |
| Cinacalcet Hydrochloride | B · Position early | - | Hypercalcaemia, Secondary hyperparathyroidism, Hyperparathyroidism | 5 | 25 | Available ×3 |
| Pemetrexed Disodium Hydrate | B · Position early | - | Non-small cell lung cancer, 间皮组织肿瘤, 胸膜孤立性纤维瘤 | 5 | 37 | Available ×3 |
| Neratinib Maleate | C · Watch | 2030 | Breast cancer | 4 | 30 | Available ×3 |
| Tasurgratinib | C · Watch | - | Biliary tract cancer, Bile duct cancer | 4 | 33 | Available ×3 |
| Gefitinib | C · Watch | - | Non-small cell lung cancer | 4 | 21 | Available ×3 |
| Rucaparib Camsylate | C · Watch | - | Prostate cancer, Peritoneal cancer, Epithelial ovarian cancer | 2 | 25 | Available ×3 |
| Golidocitinib | C · Watch | - | Peripheral T-cell lymphoma | 2 | 15 | Available ×3 |
| Conteltinib | C · Watch | - | Non-small cell lung cancer | 1 | 17 | Available ×3 |
| Maribavir | C · Watch | - | 巨细胞病毒感染 | 1 | 3 | Available ×3 |
| Folic Acid | C · Watch | - | Megaloblastic anaemia, Folate deficiency, Neural tube defect | 16 | 59 | Available ×2 |
| Diclofenac Sodium | C · Watch | - | Osteoarthritis, Rheumatoid arthritis, Ankylosing spondylitis | 10 | 45 | Available ×2 |
| Granisetron | C · Watch | - | Chemotherapy-induced nausea and vomiting, Nausea, 呕吐 | 6 | 21 | Available ×2 |
| Sorafenib Tosylate | B · Position early | - | Thyroid cancer, Hepatocellular carcinoma, Renal cell carcinoma | 5 | 14 | Available ×2 |
| Telmisartan | B · Position early | - | Hypertension | 5 | 35 | Available ×2 |
| Vismodegib | C · Watch | - | Basal cell carcinoma | 3 | 15 | Available ×2 |
| Bupivacaine | C · Watch | - | Subacromial impingement syndrome, Postoperative pain | 3 | 7 | Available ×2 |
| Lonafarnib | C · Watch | - | 早衰综合征 | 3 | 19 | Available ×2 |
| Ioflupane (123I) | C · Watch | - | Lewy body dementia, Diagnostic agent, Parkinsonism | 3 | 14 | Available ×2 |
| Pemigatinib | C · Watch | 2032 | Myeloma, Lymphoma, Bile duct cancer | 2 | 28 | Available ×2 |
| Alpelisib | C · Watch | 2029 | Growth disorder, Genetic disease, PIK3CA-related overgrowth spectrum | 2 | 17 | Available ×2 |
| Encorafenib | C · Watch | 2030 | Non-small cell lung cancer, Colorectal cancer, Thyroid cancer | 1 | 23 | Available ×2 |
| Rezivertinib Mesylate | C · Watch | - | Non-small cell lung cancer | 1 | 3 | Available ×2 |
| Vorolanib | C · Watch | - | Renal cell carcinoma | 1 | 6 | Available ×2 |
| Metoprolol Succinate | C · Watch | - | Hypertension, Angina pectoris, Heart failure | 6 | 12 | Available ×1 |
| Pralatrexate | C · Watch | - | Peripheral T-cell lymphoma | 5 | 31 | Available ×1 |
| Ibandronate Sodium Hydrate | C · Watch | - | Osteoporosis, Postmenopausal osteoporosis, Hypercalcaemia | 5 | 20 | Available ×1 |
| Cabazitaxel | C · Watch | - | Prostate cancer | 5 | 17 | Available ×1 |
| Nelfinavir Mesylate | C · Watch | - | HIV infection | 5 | 43 | Available ×1 |
| Enzalutamide | A · Act now | 2027 | Hormone-sensitive prostate cancer, Castration-resistant prostate cancer, Prostate cancer | 4 | 15 | Available ×1 |
| Belotecan Hydrochloride | C · Watch | - | Non-small cell lung cancer, Ovarian cancer | 4 | 16 | Available ×1 |
| Erdafitinib | C · Watch | 2030 | Urothelial carcinoma, Urinary tract neoplasm | 3 | 18 | Available ×1 |
| Cobicistat | C · Watch | - | HIV infection | 3 | 36 | Available ×1 |
| Pasireotide Diaspartate | C · Watch | - | Cushing's syndrome, Pituitary ACTH hypersecretion | 3 | 9 | Available ×1 |
| Azacitidine | C · Watch | - | 幼年型粒单核细胞白血病, Acute myeloid leukaemia, Myelodysplastic syndrome | 3 | 12 | Available ×1 |
| Binimetinib | C · Watch | - | Non-small cell lung cancer, Melanoma | 2 | 20 | Available ×1 |
| Olmutinib | C · Watch | - | Non-small cell lung cancer | 2 | 12 | Available ×1 |
| Inavolisib | C · Watch | - | Breast cancer, Metastatic breast cancer | 2 | 19 | Available ×1 |
| Chidamide | C · Watch | - | Diffuse large B-cell lymphoma, T-cell leukaemia, Breast cancer | 1 | 6 | Available ×1 |
| Apatinib Mesylate | C · Watch | - | Breast cancer, Gastric cancer | 1 | 6 | Available ×1 |
| Fentanyl | C · Watch | - | Pain | 1 | 6 | Available ×1 |
| Glumetinib | C · Watch | - | Non-small cell lung cancer | 1 | 6 | Available ×1 |
| Surufatinib | C · Watch | - | Neuroendocrine tumour | 1 | 5 | Available ×1 |
| Fluzoparib | C · Watch | - | Breast cancer, Peritoneal cancer, Ovarian cancer | 1 | 3 | Available ×1 |
| Amrubicin Hydrochloride | C · Watch | - | Non-small cell lung cancer, Small cell lung cancer | 1 | 9 | Available ×1 |
| Leflunomide | C · Watch | - | Rheumatoid arthritis, 狼疮肾炎, Psoriatic arthritis | 6 | 6 | - |
| Romidepsin | C · Watch | - | Peripheral T-cell lymphoma, Lymphoma | 5 | 36 | - |
| Miriplatin Hydrate | C · Watch | - | Hepatocellular carcinoma | 5 | 8 | - |
| Methylnaltrexone Bromide | C · Watch | - | Opioid dependence, Constipation, Opioid-induced constipation | 5 | 13 | - |
| Lubiprostone | C · Watch | - | Constipation, Opioid-induced constipation, Chronic idiopathic constipation | 5 | 48 | - |
| Tadalafil | B · Position early | - | Benign prostatic hyperplasia, Pulmonary hypertension, Pulmonary arterial hypertension | 5 | 16 | - |
| Efavirenz | B · Position early | - | HIV infection | 5 | 32 | - |
| Memantine Hydrochloride | B · Position early | - | Alzheimer's disease | 5 | 8 | - |
| Dutasteride | B · Position early | - | Urinary retention, Benign prostatic hyperplasia, Alopecia | 5 | 30 | - |
| Candesartan Cilexetil | B · Position early | - | Hypertension, Heart failure, Essential hypertension | 5 | 56 | - |
| Fulvestrant | B · Position early | - | Breast cancer | 5 | 27 | - |
| Etoricoxib | C · Watch | - | Osteoarthritis, 痛风性关节炎, Dysmenorrhoea | 5 | 20 | - |
| Imiquimod | C · Watch | - | Actinic keratosis, 尖锐湿疣, 角化病 | 5 | 30 | - |
| Prasterone | C · Watch | - | Vulvovaginal atrophy, Atrophy, Dyspareunia | 4 | 11 | - |
| Cevimeline Hydrochloride Hydrate | C · Watch | - | Sjögren's syndrome | 4 | 12 | - |
| Valrubicin | C · Watch | - | Bladder cancer, 原位癌 | 4 | 11 | - |
| Vinflunine Ditartrate | C · Watch | - | Urinary tract neoplasm, Urothelial carcinoma | 3 | 10 | - |
| Decitabine | C · Watch | - | Allergic reaction, Cycloplegia, Hypotension | 3 | 12 | - |
| Naloxone Hydrochloride/Oxycodone Hydrochloride Hydrate | C · Watch | - | Pain, Restless legs syndrome | 3 | 26 | - |
| Omeprazole | C · Watch | - | Heartburn, Gastro-oesophageal reflux disease, Gastric ulcer | 3 | 9 | - |
| Ritonavir | C · Watch | - | HIV infection | 3 | 40 | - |
| Artesunate | C · Watch | - | Plasmodium infection | 3 | 14 | - |
| Exemestane | C · Watch | - | Breast cancer | 3 | 8 | - |
| Lorlatinib | B · Position early | 2030 | Non-small cell lung cancer | 2 | 20 | - |
| Panobinostat Lactate | C · Watch | - | Multiple myeloma | 2 | 11 | - |
| Flutemetamol (18F) | C · Watch | - | Contrast imaging, Alzheimer's disease, Cognitive impairment | 2 | 13 | - |
| Deferasirox | B · Position early | - | Thalassaemia, Iron overload, Beta thalassaemia | 2 | 8 | - |
| Mifepristone | C · Watch | - | Cushing's syndrome, Termination of pregnancy | 2 | 9 | - |
| Risedronate Sodium Hydrate | C · Watch | - | Paget's disease, Postmenopausal osteoporosis, Osteoporosis | 2 | 3 | - |
| Flurpiridaz F-18 | C · Watch | - | Coronary artery disease, Ischaemic heart disease, Diagnostic agent | 2 | 10 | - |
| Tirbanibulin | C · Watch | - | Actinic keratosis | 2 | 12 | - |
| TLX-591 companion diagnostic (Telix Pharmaceuticals) | C · Watch | - | Prostate cancer, Diagnostic agent | 2 | 7 | - |
| Gadoxetate Disodium | C · Watch | - | Contrast imaging, Diagnostic agent | 2 | 11 | - |
| Talaporfin Sodium | C · Watch | - | Lung cancer, 脑癌 | 2 | 4 | - |
| Fedratinib | C · Watch | - | Myelofibrosis, Splenomegaly | 1 | 4 | - |
| Pexidartinib | C · Watch | - | Tenosynovial giant cell tumour | 1 | 7 | - |
| Anlotinib Dihydrochloride | C · Watch | - | Alveolar soft part sarcoma, Hepatocellular carcinoma, Endometrial cancer | 1 | 13 | - |
| Evocalcet | C · Watch | - | Secondary hyperparathyroidism | 1 | 8 | - |
| Ga-68 Edotreotide | C · Watch | - | Neuroendocrine tumour, Pancreatic neuroendocrine tumour, Diagnostic agent | 1 | 1 | - |
| Dexamethasone Cipecilate | C · Watch | - | Allergic rhinitis | 1 | 4 | - |
| Estradiol Valerate | C · Watch | - | Oestrogen deficiency syndrome, Prostate cancer, Vulvovaginal atrophy | 1 | 1 | - |
| Misoprostol | C · Watch | - | Termination of pregnancy, Duodenal ulcer, Gastric ulcer | 1 | 5 | - |
| Vorasidenib | C · Watch | - | 神经胶质瘤, 少突神经胶质瘤, 星形细胞瘤 | 1 | 6 | - |
| Omaveloxolone | C · Watch | - | Friedreich's ataxia | 1 | 4 | - |
| Pafolacianine Sodium | C · Watch | - | Lung cancer, Ovarian cancer | 1 | - | - |
| Triptorelin Pamoate | C · Watch | - | 性早熟, Prostate cancer | 1 | - | - |
| Carrimycin | C · Watch | - | Bacterial infection | - | - | - |
| Angiotensin II | C · Watch | - | Hypotension, Shock | - | - | - |
| Iron Isomaltoside | C · Watch | - | Iron deficiency anaemia | - | - | - |
| Hemoporfin | C · Watch | - | Neoplasm | - | - | - |
| Paclitaxel Oral Solution (DAE HWA Pharmaceutical) | C · Watch | - | Gastric cancer | - | - | - |
| Gallium (68Ga) oxodotreotide | C · Watch | - | Neuroendocrine tumour | - | - | - |
| Fluciclovine F 18 | C · Watch | - | Prostate cancer, Diagnostic agent | - | - | - |
| Afamelanotide | C · Watch | - | Erythropoietic protoporphyria | - | - | - |
| Pasireotide Pamoate | C · Watch | - | Acromegaly, Cushing's syndrome, Pituitary ACTH hypersecretion | - | - | - |
| Metformin acetate | C · Watch | - | Obesity, Diabetes | - | - | - |
| Liposomal bupivacaine | C · Watch | - | Pain, Postoperative pain | - | - | - |
| Sodium Fluoride F-18 | C · Watch | - | Bone metastases, Contrast imaging | - | - | - |
| Gallium (68Ga) chloride/Germanium (68Ge) chloride | C · Watch | - | Neoplasm | - | - | - |
| Thiotepa (Shorla Oncology) | C · Watch | - | Ovarian cancer, Breast cancer | - | - | - |
| Rilertinib Mesylate | C · Watch | - | Non-small cell lung cancer | - | - | - |
| Envonalkib | C · Watch | - | Non-small cell lung cancer | - | - | - |
| Imetelstat | C · Watch | - | Myelodysplastic syndrome, Anaemia | - | - | - |
| Goserelin Microspheres for Injection(1-month long acting formulation,Luye Pharma) | C · Watch | - | Breast cancer, Prostate cancer | - | - | - |
| Sovateltide | C · Watch | - | Ischaemic stroke | - | - | - |
| Befotertinib Mesylate | C · Watch | - | Non-small cell lung cancer | - | - | - |
| Flotufolastat F-18 | C · Watch | - | Prostate cancer | - | - | - |
| Triptorelin Acetate Microspheres for Injection(Shanghai Livzon Pharma) | C · Watch | - | Endometriosis, Prostate cancer | - | - | - |
| Niraparib Tosylate/Abiraterone Acetate | C · Watch | - | Hormone-sensitive prostate cancer, Castration-resistant prostate cancer | - | - | - |
| Dexmedetomidine Hydrochloride Nasal Spray(Shanghai Hengrui Pharma) | C · Watch | - | Sedation | - | - | - |
| Mitoxantrone hydrochloride liposome (CSPC ZhongQi) | C · Watch | - | Peripheral T-cell lymphoma | - | - | - |
| Nab-rapamycin | C · Watch | - | 血管周上皮样细胞瘤 | - | - | - |
| Paclitaxel Polymeric Micelles (Shanghai Yizhong Pharmaceutical) | C · Watch | - | Non-small cell lung cancer | - | - | - |
| Boanmycin hydrochloride | C · Watch | - | Head and neck cancer | - | - | - |
| Yttrium[90Y] | C · Watch | - | Liver cancer, Colorectal cancer | - | - | - |
| Arsenic Trioxide | C · Watch | - | Liver cancer, Acute promyelocytic leukaemia | - | - | - |
| Lopinavir/Ritonavir | B · Position early | - | HIV infection | - | - | - |
| Budesonide/Formoterol fumarate dihydrate | B · Position early | - | Chronic obstructive pulmonary disease, Asthma | - | - | - |
| Dihydroetorphine Hydrochloride | C · Watch | - | Cancer pain, Postoperative pain | - | - | - |
| Tegafur/Gimeracil/Oteracil Potassium | C · Watch | - | Gastric cancer, Bile duct cancer, Non-small cell lung cancer | - | - | - |
| Arsenious Acid | C · Watch | - | Multiple myeloma, Lung cancer, Liver cancer | - | - | - |
| Icosapent ethyl | C · Watch | - | Hypertriglyceridaemia, Cardiac and vascular disorders, Dyslipidaemia | - | - | - |
| Perflutren | C · Watch | - | Contrast imaging, Cardiovascular contrast agent | - | - | - |
| Samarium (153Sm) lexidronam pentasodium | C · Watch | - | Pain | - | - | - |
| Kanglaite | C · Watch | - | Non-small cell lung cancer, Liver cancer | - | - | - |
| [225Ac]Ac-FL-261 | C · Watch | - | Solid tumour, Non-small cell lung cancer | - | - | - |
| Alpha-lactalbumin-oleic acid (Azanta) | C · Watch | - | Bladder cancer | - | - | - |
| ONO-4578 | C · Watch | - | 食道腺癌, 食管胃结合部肿瘤, Gastric cancer | - | - | - |
| FHD-286 | C · Watch | - | Small cell lung cancer, Myelodysplastic syndrome, Acute myeloid leukaemia | - | - | - |
| 64CU-DOTA-ECL1i | C · Watch | - | Head and neck squamous cell carcinoma, 动脉硬化, 颈动脉疾病 | - | - | - |
| 64Cu-TR2205 | C · Watch | - | Prostate cancer, Diagnostic agent | - | - | - |
| JYP-0035 | C · Watch | - | Breast cancer, Solid tumour | - | - | - |
| 68Ga-FAPI/18F-FDG | C · Watch | - | Oesophageal cancer, 食管鳞状细胞癌 | - | - | - |
| HTX-201 | C · Watch | - | EB病毒感染, Kidney transplant rejection, Urothelial carcinoma | - | - | - |
| [18F]BF3-BPA | C · Watch | - | 脑癌, 脑部造影剂 | - | - | - |
| ND-003 (NewDEL Biotech) | C · Watch | - | Idiopathic pulmonary fibrosis, Gastrointestinal stromal tumour, 肾脏纤维化 | - | - | - |
| Lumekefamide | C · Watch | - | Cancer pain, Postoperative pain | - | - | - |
| Inobrodib | C · Watch | - | Multiple myeloma, Non-Hodgkin lymphoma, Myelodysplastic syndrome | - | - | - |
| RG-6457 | C · Watch | - | Colorectal cancer, Solid tumour | - | - | - |
| OTR-8100 | C · Watch | - | Neoplasm | - | - | - |
| Zopocianine | C · Watch | - | Prostate cancer | - | - | - |
| BH015 | C · Watch | - | Bladder cancer | - | - | - |
| SRG-514 | C · Watch | - | 三阴性乳腺癌, Breast cancer | - | - | - |
| HSK-42360 | C · Watch | - | Colorectal cancer, 脑癌, Solid tumour | - | - | - |
| PAX-1-001 | C · Watch | - | Cancer pain | - | - | - |
| ANS-02 | C · Watch | - | Non-small cell lung cancer, Solid tumour | - | - | - |
| APG-157 | C · Watch | - | 口腔癌, Oral squamous cell carcinoma, 口咽部鳞状细胞癌 | - | - | - |
| [68Ga]BED003 | C · Watch | - | Colorectal cancer, Epithelial ovarian cancer, Gastric cancer | - | - | - |
| JMKX-000197 | C · Watch | - | 恶性胸腔积液, Bladder cancer, Solid tumour | - | - | - |
| 68Ga-PSMA-0057 | C · Watch | - | Castration-resistant prostate cancer, Prostate cancer | - | - | - |
| DN-022150 | C · Watch | - | Pancreatic cancer, Solid tumour | - | - | - |
| Atebimetinib | C · Watch | - | Adenocarcinoma, Pancreatic cancer, 胰腺导管癌 | - | - | - |
| BLU-924 | C · Watch | - | Non-small cell lung cancer, Colorectal cancer, Solid tumour | - | - | - |
| AZD-2287 | C · Watch | - | Prostate cancer, Castration-resistant prostate cancer | - | - | - |
| TR-115 | C · Watch | - | 结外NK-T细胞淋巴瘤, Peripheral T-cell lymphoma, 成熟T细胞和NK细胞淋巴瘤 | - | - | - |
| DAT-2645 | C · Watch | - | Ovarian cancer, Solid tumour, Colorectal cancer | - | - | - |
| HRS-7058 | C · Watch | - | Non-small cell lung cancer, Pancreatic cancer, Solid tumour | - | - | - |
| AZD-2265 | C · Watch | - | Castration-resistant prostate cancer, Prostate cancer | - | - | - |
| Zn-Telomir | C · Watch | - | 三阴性乳腺癌 | - | - | - |
| LN-003 | C · Watch | - | Castration-resistant prostate cancer | - | - | - |
| Azenosertib | C · Watch | - | Ovarian cancer, 浆液性囊腺癌, 子宫肿瘤 | - | - | - |
| [11C]CS1P1 | C · Watch | - | Brain metastases, 中枢神经系统肿瘤, Alzheimer's disease | - | - | - |
| Abenacianine | C · Watch | - | Lung cancer | - | - | - |
| TQ-B3234 | C · Watch | - | Plexiform neurofibroma, Neurofibromatosis type I, Neoplasm | - | - | - |
| HRS-6208 | C · Watch | - | Breast cancer, Solid tumour | - | - | - |
| Gemcitabine Hydrochloride/Docetaxel | C · Watch | - | Bladder cancer, Urinary tract neoplasm, 转移性上皮癌 | - | - | - |
| HB-5 | C · Watch | - | 基底鳞状细胞癌, 原位癌, Acne vulgaris | - | - | - |
| SNB-101 | C · Watch | - | Small cell lung cancer, Gastric cancer, Colorectal cancer | - | - | - |
| TB511 | C · Watch | - | Non-small cell lung cancer, Hepatocellular carcinoma, Colorectal cancer | - | - | - |
| Terbium 161 DOTATATE PRRT | C · Watch | - | Neuroendocrine carcinoma, Neuroendocrine tumour | - | - | - |
| CMS-D002 | C · Watch | - | 子宫肌瘤, 子宫肿瘤, Endometriosis | - | - | - |
| [18F]FPyQCP | C · Watch | - | Colorectal cancer, Epithelial ovarian cancer, Gastric cancer | - | - | - |
| Setidegrasib | C · Watch | - | Non-small cell lung cancer, Pancreatic cancer, 胰腺导管癌 | - | - | - |
| Flonoltinib maleate | C · Watch | - | Myelofibrosis, 丝虫病, 红细胞增多症 | - | - | - |
| BL-0020 | C · Watch | - | Small cell lung cancer, 三阴性乳腺癌, Pancreatic cancer | - | - | - |
| EIK1005 | C · Watch | - | 错配修复基因缺陷型肿瘤, 高微卫星不稳定性癌症, Colorectal cancer | - | - | - |
| INI-2004 | C · Watch | - | Allergic rhinitis, 食物过敏, Respiratory tract infection | - | - | - |
| Nenocorilant | C · Watch | - | Neoplasm | - | - | - |
| XNW-34017 | C · Watch | - | Solid tumour, Metastatic cancer | - | - | - |
| Amifostine for nasoduodenal delivery (Xerient Pharma) | C · Watch | - | Pancreatic cancer | - | - | - |
| BI-882370 | C · Watch | - | Non-small cell lung cancer, Melanoma, Thyroid cancer | - | - | - |
| Vopenfasinib | C · Watch | - | Ovarian cancer, Solid tumour, Small cell lung cancer | - | - | - |
| 177Lu-PSMA-0057 | C · Watch | - | Castration-resistant prostate cancer, Prostate cancer | - | - | - |
| TYK-01054 | C · Watch | - | Solid tumour, 间皮组织肿瘤, Sarcoma | - | - | - |
| KN-510 | C · Watch | - | 胰腺导管癌, Solid tumour | - | - | - |
| KN-713 | C · Watch | - | 胰腺导管癌, Solid tumour | - | - | - |
| Vepugratinib | C · Watch | - | Urothelial carcinoma, Bladder cancer, Metastatic cancer | - | - | - |
| 18F-LNC1007 | C · Watch | - | Renal cell carcinoma, Solid tumour, Diagnostic agent | - | - | - |
| FT-2109 | C · Watch | - | 肠道疾病, Intestinal neoplasm, 结肠疾病 | - | - | - |
| BB-102 | C · Watch | - | Hepatocellular carcinoma, Solid tumour | - | - | - |
Frequently asked questions
Which patent-cliff drugs in Oncology & Hematology are worth tracking?
239 drugs related to Oncology & Hematology are tracked on this site, 135 of them with recorded synthesis routes. See the table above and open each drug profile for routes and intermediates.
Where can I source Oncology & Hematology intermediates?
Key intermediates of 89 drugs in this table are available through the Unibest supply network; for the rest, submit an RFQ per CAS on the intermediate profile pages.
Where can I check patent expiry for these drugs?
Each drug profile shows the public expiry year; yearly overviews are available at /patent-cliff/expires/<year>.
Source: cross-verified structured fields · Classification: indication keywords + explicit molecule lists · 2026-09-29